Abstract
(Appeared originally in Brain Stimulation 2020; 13:1805–1812)
Reprinted with permission from Elsevier
. 2022 Jan 25;20(1):90–99. doi: 10.1176/appi.focus.20109
Sonication of the Anterior Thalamus With MRI-Guided Transcranial Focused Ultrasound (tFUS) Alters Pain Thresholds in Healthy Adults: A Double-Blind, Sham-Controlled Study
Bashar W Badran
1,✉, Kevin A Caulfield
1, Sasha Stomberg-Firestein
1, Philipp M Summers
1, Logan T Dowdle
1, Matt Savoca
1, Xingbao Li
1, Christopher W Austelle
1, E Baron Short
1, Jeffrey J Borckardt
1, Norman Spivak
1, Alexander Bystritsky
1, Mark S George
1
Bashar W Badran
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
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Kevin A Caulfield
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
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Sasha Stomberg-Firestein
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
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Philipp M Summers
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
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Logan T Dowdle
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
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Matt Savoca
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
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Xingbao Li
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
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Christopher W Austelle
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
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E Baron Short
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
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Jeffrey J Borckardt
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
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Norman Spivak
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
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Alexander Bystritsky
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
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Mark S George
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
Find articles by Mark S George
1Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; University of California, Los Angeles, Los Angeles, CA, USA; BrainSonix Corporation, Sherman Oaks, CA, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
✉
Corresponding author. Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, USA. E-mail address: badran@musc.edu (B.W. Badran).
✉
Corresponding author.
Received 2020 May 11; Revised 2020 Oct 12; Accepted 2020 Oct 12; Issue date 2022 Jan.
Copyright © 2022 by the American Psychiatric Association
PMCID: PMC9063607 PMID: 35746940