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Schematic illustration of the synthesis, encapsulation and application of 4-OI@Zn-NH-pyr for enhanced therapy in severe joint inflammation. (A) Synthesis, encapsulation and protonation of 4-OI@Zn-NH-pyr. (B) Application of 4-OI@Zn-NH-pyr in management of TMJ inflammation by suppressing inflammatory macrophages and OCs. 4-OI@Zn-NH-pyr can alleviate inflammation and ROS production high-efficiently via multiple approaches.
