Volume 45, no. 4, p. 1086–1093, 2001. Page 1090, column 1, lines 1 to 5: “did not show any … or its metabolites” should read “showed no significant differences in exposure to either the parent drug or its metabolites between the first dose and steady state (Table 3); however, this analysis was not designed or powered to rule out modest changes in clearance or exposure, and the trend for increased M8-to-nelfinavir concentration ratio on day 28 may reflect modest induction of metabolism during multiple dosing.”
. 2001 Aug;45(8):2405.
Circulating Metabolites of the Human Immunodeficiency Virus Protease Inhibitor Nelfinavir in Humans: Structural Identification, Levels in Plasma, and Antiviral Activities
Kanyin E Zhang
1, Ellen Wu
1, Amy K Patick
1, Bradley Kerr
1, Mark Zorbas
1, Angela Lankford
1, Takuo Kobayashi
1, Yuki Maeda
1, Bhasker Shetty
1, Stephanie Webber
1
Kanyin E Zhang
1Pfizer Global Research and Development, La Jolla, California, and Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka 569, Japan
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Ellen Wu
1Pfizer Global Research and Development, La Jolla, California, and Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka 569, Japan
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Amy K Patick
1Pfizer Global Research and Development, La Jolla, California, and Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka 569, Japan
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Bradley Kerr
1Pfizer Global Research and Development, La Jolla, California, and Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka 569, Japan
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Mark Zorbas
1Pfizer Global Research and Development, La Jolla, California, and Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka 569, Japan
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Angela Lankford
1Pfizer Global Research and Development, La Jolla, California, and Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka 569, Japan
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Takuo Kobayashi
1Pfizer Global Research and Development, La Jolla, California, and Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka 569, Japan
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Yuki Maeda
1Pfizer Global Research and Development, La Jolla, California, and Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka 569, Japan
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Bhasker Shetty
1Pfizer Global Research and Development, La Jolla, California, and Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka 569, Japan
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Stephanie Webber
1Pfizer Global Research and Development, La Jolla, California, and Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka 569, Japan
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1Pfizer Global Research and Development, La Jolla, California, and Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka 569, Japan
Copyright © 2001, American Society for Microbiology
PMCID: PMC90668