Yee Kit Tai
Yee Kit Tai
1
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
2
Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, Singapore, Singapore
1,2,
Karen Ka Wing Chan
Karen Ka Wing Chan
1
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
2
Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, Singapore, Singapore
1,2,
Charlene Hui Hua Fong
Charlene Hui Hua Fong
1
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
2
Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, Singapore, Singapore
1,2,
Sharanya Ramanan
Sharanya Ramanan
1
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
2
Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, Singapore, Singapore
1,2,
Jasmine Lye Yee Yap
Jasmine Lye Yee Yap
1
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
2
Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, Singapore, Singapore
1,2,
Jocelyn Naixin Yin
Jocelyn Naixin Yin
1
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
2
Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, Singapore, Singapore
1,2,
Yun Sheng Yip
Yun Sheng Yip
3
Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore
3,
Wei Ren Tan
Wei Ren Tan
3
Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore
3,
Angele Pei Fern Koh
Angele Pei Fern Koh
4
Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
4,
Nguan Soon Tan
Nguan Soon Tan
3
Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore
5
School of Biological Sciences, Nanyang Technological University Singapore, Singapore, Singapore
3,5,
Ching Wan Chan
Ching Wan Chan
6
Division of General Surgery (Breast Surgery), Department of Surgery, National University Hospital, Singapore, Singapore
7
Division of Surgical Oncology, National University Cancer Institute, Singapore, Singapore
6,7,
Ruby Yun Ju Huang
Ruby Yun Ju Huang
4
Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
8
Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
4,8,
Jing Ze Li
Jing Ze Li
1
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
1,
Jürg Fröhlich
Jürg Fröhlich
1
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
9
Fields at Work GmbH, Zürich, Switzerland
10
Institute of Electromagnetic Fields, ETH Zürich (Swiss Federal Institute of Technology in Zürich), Zürich, Switzerland
1,9,10,
Alfredo Franco-Obregón
Alfredo Franco-Obregón
1
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
2
Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, Singapore, Singapore
11
Institute for Health Innovation & Technology (iHealthtech), National University of Singapore, Singapore, Singapore
12
Competence Center for Applied Biotechnology and Molecular Medicine, University of Zürich, Zürich, Switzerland
13
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
14
Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
1,2,11,12,13,14,*
1
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
2
Biolonic Currents Electromagnetic Pulsing Systems Laboratory (BICEPS), National University of Singapore, Singapore, Singapore
3
Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore
4
Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
5
School of Biological Sciences, Nanyang Technological University Singapore, Singapore, Singapore
6
Division of General Surgery (Breast Surgery), Department of Surgery, National University Hospital, Singapore, Singapore
7
Division of Surgical Oncology, National University Cancer Institute, Singapore, Singapore
8
Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
9
Fields at Work GmbH, Zürich, Switzerland
10
Institute of Electromagnetic Fields, ETH Zürich (Swiss Federal Institute of Technology in Zürich), Zürich, Switzerland
11
Institute for Health Innovation & Technology (iHealthtech), National University of Singapore, Singapore, Singapore
12
Competence Center for Applied Biotechnology and Molecular Medicine, University of Zürich, Zürich, Switzerland
13
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
14
Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Edited and reviewed by: Tarik Smani, Sevilla University, Spain
✉*Correspondence: Alfredo Franco-Obregón, suraf@nus.edu.sg
This article was submitted to Cancer Molecular Targets and Therapeutics, a section of the journal Frontiers in Oncology
Received 2022 Mar 9; Accepted 2022 Mar 31; Collection date 2022.
Keywords: breast cancer, PEMFs, EMT, patient-derived xenograft, chorioallantoic membrane, doxorubicin, TRPC1, chemotherapy
Copyright © 2022 Tai, Chan, Fong, Ramanan, Yap, Yin, Yip, Tan, Koh, Tan, Chan, Huang, Li, Fröhlich and Franco-Obregón
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.