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. 2022 Apr 9;163(5):bqac046. doi: 10.1210/endocr/bqac046

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Figure 3. — Effects of STAT5_CA and cGH infusion on sex-biased gene expression. (A) Heatmap showing impact of STAT5_CA or cGH infusion on the expression of 275 responsive sex-biased genes (log2 fold-change increases or decreases) in male mouse liver as indicated. M, male; F, female. (B) Overlap between female-biased genes induced by AAV8-STAT5_CA and those induced by cGH after either 7 or 14 days (left), and between male-biased genes repressed by AAV8-STAT5_CA and those repressed by cGH after either 7 or 14 days (right). Excluded are 5 male-biased genes induced by AAV8-STAT5_CA and 1 female-biased genes repressed by AAV8-STAT5_CA. (C) Boxplots showing the distribution of feminization values for 139 female-biased genes induced in male liver in both mouse models (see Table S2) (42). Median value, horizontal line in each box.