Correction: Mechanical stress shapes the cancer cell response to neddylation inhibition

Correction to: J Exp Clin Cancer Res 41, 115 (2022)

https://doi.org/10.1186/s13046-022-02328-y

Following publication of the original article [1], an error was identified in Fig. 1; specifically:

• Fig. 1b: Incorrect image used for Pulse-MLN cells (bottom right panel); the correct image is now used

Fig. 1.

Neddylation inhibition induces distinct phenotypes in PCa cells. A, B Effect of 100 nM MLN on PCa colony growth in soft agar (“steady”). In the “pulse” regimen, the cells were pretreated with 100 nM MLN for 1 h before seeding (see also Supplementary Figure S1A). The histograms show the colony size distribution of control (black)- and MLN (red)-treated cells. The numbers indicate the total area occupied by the colonies of the given size. Scale bar = 1 mm. C, D Wound healing assay with LNCaP (C) and PC3 (D) cells (mean ±} S.D., n = 5 for LNCaP, n = 6 for PC3, ***-p < 0.001). 100 nM MLN was added just before monolayer scratching. Scale bar = 500 μm (E, F) Effect of 100 nM MLN on LNCaP (E) and PC3 (F) tumoroid growth over 10 days. Scale bar = 150 μm. In all experiments with MLNs, DMSO was used as a vehicle control

The corrected figure is given here. The correction does not have any effect on the final conclusions of the paper. The original article has been corrected.