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. 2022 May 7;38(4):847–855. doi: 10.1007/s40242-022-2087-9

Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation

Sisi Chen 1,#, Lei Zhang 1,#, Quan Yuan 1,✉, Jie Tan 1,✉
PMCID: PMC9077342  PMID: 35573821

Abstract

The interaction between biomolecules with their target ligands plays a great role in regulating biological functions. Aptamers are short oligonucleotide sequences that can specifically recognize target biomolecules via structural complementarity and thus regulate related biological functions. In the past ten years, aptamers have made great progress in target biomolecule recognition, becoming a powerful tool to regulate biological functions. At present, there are many reviews on aptamers applied in biomolecular recognition, but few reviews pay attention to aptamer-based regulation of biological functions. Here, we summarize the approaches to enhancing aptamer affinity and the advancements of aptamers in regulating enzymatic activity, cellular immunity and cellular behaviors. Furthermore, this review discusses the challenges and future perspectives of aptamers in target recognition and biological functions regulation, aiming to provide some promising ideas for future regulation of biomolecular functions in a complex biological environment.

Keywords: Aptamer, Molecular recognition, Biological process regulation

Acknowledgements

This work was supported by the National Natural Science Foundation of China(Nos.22174038, 21925401, 21904037).

Footnotes

Conflicts of Interest

The authors declare no conflicts of interest.

These authors contributed equally to this work.

Contributor Information

Quan Yuan, Email: yuanquan@whu.edu.cn.

Jie Tan, Email: tanjie0416@hnu.edu.cn.

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