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. 2022 May 7;286:121570. doi: 10.1016/j.biomaterials.2022.121570

Fig. 5.

Fig. 5

Reporter protein expression in BALB/c mice after IM injection of hEPO and FLuc mRNAs loaded in DOG-IM4 or L319 LNPs. Panel A: In vivo imaging of Balb/c mice 6h and 24h after IM administration of a 5 μg dose of Fluc mRNA in DOG-IM4 or L319 LNPs under 50 μL of PBS. One representative mouse from groups of 4 is shown for each formulation.Panel B: Luciferase expression from the injected muscles was quantified and average Radiance (total photon flux/second) (±SD) from groups of 4 injected mice is represented as a function of time.Panel C: Average (±SD) hEPO expression in the serum of Balb/c mice (4/group) determined by ELISA 6h and 24h after IM administration of 1 μg of hEPO mRNA in either DOG-IM4 or L319 LNPs under 50 μl of PBS.