Table 2.

Brain regions with smaller rGMV in lonely subjects diagnosed as pre-AD dementia status (SCD [n = 39] and MCI [n = 53]) compared with non-lonely subjects

	Brain regions	MNI coordinates			T value	P	Cluster size (voxels)
		x	y	z
SCD	Right thalamus	18	− 26	4	5.27	0.020 (FWE-corr)	1002
	Left thalamus	− 8	− 24	12	4.77	0.050 (FWE-corr)	771
MCI	Cerebellar vermal lobules	− 6	− 45	− 6	5.04	0.004 (FEW-corr)	1474
	Left middle occipital gyrus	− 36	− 88	18	4.86	0.031 (uncorrected)	477

AD, Alzheimer’s disease; FWE-corr, family wise error corrected; MCI, mild cognitive impairment; rGMV, regional gray matter volume; MNI coordinates, Montreal Neurological Institute coordinates; SCD, subjective cognitive decline