Fig. 7.
Robustness of signal-oriented analysis towards slight changes of ROIs. Animal-ROIs were derived by automated segmentation via DL and by manual annotation of three experimenters. The signal-oriented analysis was applied separately for each of the four sets of animal-ROIs. AUC values were calculated for Sham and PCI animals as well as the corresponding p-values and effect sizes, confirming high compliance between the different ROI sets (DL: p = 8.2 ∙ 10−5, g = 1.89; Experimenter 1: p = 2.7 ∙ 10−5, g = 1.88; Experimenter 2: p = 3.8 ∙ 10−4, g = 1.86; Experimenter 3: p = 8.2 ∙ 10−5, g = 1.85; p-values were derived by two-tailed Wilcoxon rank sum test; g-values denote Hedges' g). The black triangles indicate mean values, and the yellow dots represent individual data points.