Appendix 3—table 1. Genetic effects and pharmaco-genetic interactions in study 1.

Columns are organized as in Table 1 of the main text. Mismatch ERPs in volatile periods were differentially modulated by CHAT polymorphism in the placebo versus the biperiden group, whereas mismatch ERPs overall and in stable periods were modulated by COMT polymorphism in the amisulpride group.

Study 1: Genetic effects	cluster	$x\left[\mathrm{m}\mathrm{m}\right]$	$y\left[\mathrm{m}\mathrm{m}\right]$	$z\left[\mathrm{m}\mathrm{s}\right]$	$t_{63}$	$Z_{\equiv }$	$p_{FWE}$	$k_E$	$t{w}_{sig}$[ms]
A volatile mismatch: CHAT: PLA >BIP	1	–34	–52	380	5.77	5.15	0.001	302	356–392
B volatile mismatch: PLA: pos. effect of CHAT	1	–34	–46	384	4.57	4.23	0.032	6	380–384
C volatile mismatch: BIP: neg. effect of CHAT	1	–51	–25	384	4.49	4.17	0.040	6	380–384
D mismatch: AMI: pos. effect of COMT	1	0	–73	304	4.51	4.18	0.033	18	300–308
E mismatch: AMI: neg. effect of COMT	1	42	–19	300	4.79	4.41	0.014	33	292–304
F stable mismatch: AMI: neg. effect of COMT	1	42	–14	300	4.44	4.12	0.042	6	300–304