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. 2022 Apr 28;27(9):2823. doi: 10.3390/molecules27092823

Figure 1.

Figure 1

The active site of ERα in the apo form (PDB ID: 4Q13 [21]) (A); in complex with 17β-estradiol (PDB ID: 1ERE [13], i.e., agonist/partial agonist) (B); in complex with Raloxifene (PDB ID: 1ERR [13], i.e., SERM antagonist) (C); in complex with GW568 (PDB ID: 1R5K [21], i.e., SERD antagonist) (D). The residues depicted as white sticks and ribbons belong to the helices H3 (residues 332–354), H6 (residues 383–394), H7 (residues 429–438), H11 (residues 517–528), H12 (residues 531–547), loop (residues 418–428), and S1 and S2 antiparallel β-sheets (residues 402–410). H12 helix is depicted as a blue ribbon, as a crucial delimiter for partial agonists, SERMs, and SERDs.