Table 2.

The inhibitory effects of 2,5-diaminobenzoxazole derivatives on IL- 6 and IL-1β mRNA from macrophages.

Raw 264.7	IL-6 mRNA Inhibition (%)		IL-1β mRNA Inhibition (%)
Compound	1 μg/mL	10 μg/mL	1 μg/mL	10 μg/mL
LPS	0.0 ± 0.91		0.0 ± 0.02
3a	33.64 ± 1.05 **	44.12 ± 0.25 **	89.01 ± 1.19 **	95.08 ± 0.88 **
3e	65.03 ± 0.52 **	76.10 ± 1.11 **	75.55 ± 2.01 **	78.75 ± 0.98 **
3a + 3e	40.55 ± 0.71 **	45.21 ± 1.03 **	82.55 ± 0.77 **	83.66 ± 0.90 **

** p < 0.01 compared with the group treated with the LPS alone. Data are presented as the mean ± SD.