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. 2022 May 3;11(9):1528. doi: 10.3390/cells11091528

Figure 2.

Figure 2

LINC00152 and putative miRNAs were enriched in RNP complexes in a potential LINC00152-driven ceRNA network in human HCC. (A) LINC00152 expression in human HCC cell lines. (B) LINC00152 mRNA is enriched in AGO2 complexes of HCC cell lines compared to IgG control. (C,D) The predicted miRNAs components of the LINC00152 ceRNA network are significantly more prevalent in AGO2-immunoprecipitated protein complexes of HuH7 and HepG2 cells compared to control. Data are presented as mean ± SD of 3 technical replicates in panel (A) or 4 independent experiments in (B–D). Welch’s t-test: * p < 0.05, ** p < 0.01, *** p < 0.001. Abbreviations: NL, normal liver tissue; AGO2, Argonaute-2; IgG, immunoglobulin G; rel., relative.