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. 2022 Feb 16;38(3):621225. doi: 10.1007/s10409-021-09045-x

Coordinated motion of molecular motors on DNA chains with branch topology

分支拓扑DNA链上分子马达的协调运动

Di Lu 1, Bin Chen 1,2,✉
PMCID: PMC9109741  PMID: 35601132

Abstract

To understand the macroscopic mechanical behaviors of responsive DNA hydrogels integrated with DNA motors, we constructed a state map for the translocation process of a single FtsKC on a single DNA chain at the molecular level and then investigated the movement of single or multiple FtsKC motors on DNA chains with varied branch topologies. Our studies indicate that multiple FtsKC motors can have coordinated motion, which is mainly due to the force-responsive behavior of individual FtsKC motors. We further suggest the potential application of motors of FtsKC, together with DNA chains of specific branch topology, to serve as strain sensors in hydrogels.

Keywords: DNA, Molecular motor, Coordinated motion, Branch topology, Strain sensor

Footnotes

This work was supported by the National Natural Science Foundation of China (Grant No. 11872334).

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