Figure 6. Extensions of Specific Nuclear-Anchored Independent Labeling (SNAIL) technologies in primates.

(a) Receiver operator characteristic and precision-recall performance metrics for parvalbumin-expressing (PV+) support vector machines (SVMs) derived from single-nucleus chromatin accessibility assays of human cortical tissue. The reported numbers are the areas under the curve for each model. (b) Comparison of mouse PV+ open chromatin sequences scored by mouse and human SVMs. Axes are the mean SVM scores among the 11 mouse SVMs or 4 human SVMs. (c) Images of SC1 AAV activation in the rhesus macaque cortex. (d) Quantification of SC1 and Pvalb antibody staining in the macaque cortex. Image sets near the center or peripheral of the injection site were quantified separately.