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. 2022 Feb 23:10.1111/odi.14159. Online ahead of print. doi: 10.1111/odi.14159

Sicca symptoms in post‐acute COVID‐19 syndrome

Thayanara Silva Melo 1,2, Renata Cristina Beltrão 2, Andréia de Fátima Trindade de Mendonça 2, Ângela Luzia Branco Pinto Duarte 3, Luiz Alcino Gueiros 1,2,✉
PMCID: PMC9115503  PMID: 35176193

CONFLICTS OF INTEREST

None to declare.

AUTHOR CONTRIBUTIONS

Thayanara Silva Melo: Investigation; Writing – original draft; Writing – review & editing. Renata Cristina Beltrão: Conceptualization; Data curation; Writing – original draft. Andréia Fátima Mendonça: Data curation; Visualization; Writing – original draft. Angela Duarte: Conceptualization; Supervision; Writing – review & editing. Luiz Alcino Gueiros: Project administration; Supervision; Writing – review & editing.

PEER REVIEW

The peer review history for this article is available at https://publons.com/publon/10.1111/odi.14159.

Dear Editor,

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was first identified in December 2019 and has caused a worldwide pandemic (Zhu et al., 2020). In addition to the unprecedented global scale morbidity and mortality associated with the acute phase, several conditions have been described in the post‐infectious phase—the post‐acute COVID‐19 syndrome (Nalbandian et al., 2021). This condition may share similarities to other post‐acute viral syndromes described in survivors of other virulent coronavirus epidemics and seems to include symptoms such as dyspnea, chest pain, cognitive disturbances, arthralgia, and decline in quality of life (Carfi et al., 2020; Huang et al., 2021; Tenforde et al., 2020).

The post‐acute COVID‐19 syndrome can be classified as subacute or ongoing symptomatic COVID‐19, including symptoms 4–12 weeks beyond acute COVID‐19. On the other hand, chronic or post‐COVID‐19 syndrome conditions are observed after 12 weeks of acute onset and are not attributable to alternative diagnoses (Nalbandian et al., 2021). Symptoms may follow non‐critical COVID‐19 and affect more than 70% of individuals. Fatigue and sleep difficulties are the most commonly observed conditions (Huang et al., 2021). Yet, a better characterization of this syndrome is still lacking.

In this context, oral features of the post‐COVID‐19 syndrome are yet not described. The rehabilitation unit for survivors of severe COVID‐19, located in a tertiary University Hospital in Northeast Brazil, has currently analyzed 22 individuals. The unit admits adult patients who have recovered from critical (PCR‐confirmed) COVID‐19 and stayed at least three days in the ICU, promoting multi‐professional care, including specialists in oral medicine, speech therapy, physical therapy, nutrition, intensive care, pneumology, and infectious diseases. We have observed an intriguing manifestation of this syndrome: sicca symptoms lasting more than six months. We have evaluated 22 patients,12/22 males with a mean age of 56.4 years old and an average length of stay in the ICU of eight days, and 9/22 required mechanical ventilation. Arterial hypertension (85%) and type II diabetes (6%) were the most commonly observed comorbidities.

The oral medicine specialist consultation was performed after admission to the unit. The mean time since hospital discharge was 155 days (sd = 21 days, ranging from 62–210 days). Schirmer I test considered positive for severe dry eye (≤5 mm/5 min) in 16/22 (72, 72%) individuals. The median resting salivary flow was 0.07 ml/min, ranging from 0.0 to 1.3 ml/min, and 12/22 (54, 54%) individuals presented a reduced RSF (≤0.1 ml/min).

Xerostomia has been reported as a relevant symptom in COVID‐19 individuals(Amorim Dos Santos et al., 2021), but xerophthalmia has not been associated with this disease(Costa et al., 2021). Nevertheless, our group has recently reported an impressive elevation of Sjögren's syndrome notification (Martelli Junior et al., 2021) during the COVID‐19 pandemic in Brazil. Also, the clinical profile of our small cohort is somewhat distinctive from regular SS patients, being composed of a majority of male individuals (54, 54%). Interestingly, oral dryness was not considered a relevant aspect of post‐COVID‐19 syndrome by Costa et al. (2021), even though their population was less than 30% of critical COVID‐19 cases (Martelli Junior et al., 2021). Notwithstanding, whether this sicca syndrome represents actual Sjögren's syndrome should be better evaluated. Interestingly, a post‐COVID‐19 syndrome in patients with primary Sjögren's syndrome has a frequency of nearly 60% and is associated with hospitalization, baseline CRP levels, and hydroxychloroquine levels, but worsens sicca symptoms were not reported (Brito‐Zerón et al., 2021). Also, the impact of these features on oral health should be a matter of concern for future prospective cohort studies.

The long‐term consequences of COVID‐19 are not yet fully understood, and information in the literature is still limited. Our study shows significant changes that should be investigated in this patient profile, highlighting the importance of monitoring these patients after COVID‐19.

1. ACKNOWLEDGMENTS

Dr. Thayanara Silva Melo received a Ph.D scholarship from The Pernambuco Research Foundation (FACEPE).

Melo, T. S. , Beltrão, R. C. , Mendonça, A. D. F. T. D. , Duarte, Â. L. B. P. , & Gueiros, L. A. (2022). Sicca symptoms in post‐acute COVID‐19 syndrome. Oral Diseases, 00, 1–2. 10.1111/odi.14159

REFERENCES

  1. Amorim Dos Santos, J. , Normando, A. G. C. , Carvalho da Silva, R. L. , Acevedo, A.C. , De Luca Canto, G. , Sugaya, N. , Santos‐Silva, A.R. , & Guerra, E.N.S. (2021). Oral manifestations in patients with COVID‐19: A living systematic review. Journal of Dental Research, 100(2), 141–154. 10.1177/0022034520957289 [DOI] [PubMed] [Google Scholar]
  2. Brito‐Zerón, P. , Acar‐Denizli, N. , Romão, V. C. , Armagan, B. , Seror, R. , Carubbi, F. , Melchor, S. , Priori, R. , Valim, V. , Retamozo, S. , Pasoto, S. G. , Trevisani, V. F. M. , Hofauer, B. , Szántó, A. , Inanc, N. , Hernández‐Molina, G. , Sebastian, A. , Bartoloni, E. , Devauchelle‐Pensec, V. , … Ramos‐Casals, M. (2021). Post‐COVID‐19 syndrome in patients with primary Sjögren's syndrome after acute SARS‐CoV‐2 infection. Clinical and Experimental Rheumatology, 39 Suppl 133(6), 57–65. [DOI] [PubMed] [Google Scholar]
  3. Carfi, A. , Bernabei, R. , & Landi, F. (2020). Gemelli against COVID‐19 Post‐Acute Care Study Group. Persistent symptoms in patients after acute COVID‐19. Journal of the American Medical Association, 324, 603–605. 10.1001/jama.2020.12603 [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Costa, I. F. , Bonifacio, L. P. , Bellissimo‐Rodrigues, F. , Rocha, E.M. , Jorge, R. , Bollela, V.R. , & Antunes‐Foschini, R. (2021). Ocular findings among patients surviving COVID‐19. Scientific Reports, 11(1), 11085. 10.1038/s41598-021-90482-2 [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Huang, C. , Huang, L. , Wang, Y. , Li, X. , Ren, L. & Gu, X. (2021). 6‐month consequences of COVID‐19 in patients discharged from hospital: A cohort study. Lancet, 397, 220–232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Martelli Junior, H. , Machado, R. A. , Bonan, P. R. F. , Perez, D. , Pires, F. R. , & Alves, F. A. (2021). Brazilian oral medicine and oral pathology: We are here during the COVID‐19 pandemic. Oral Diseases, 27(Suppl 3), 757–759. 10.1111/odi.13440 [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Nalbandian, A. , Sehgal, K. , Gupta, A. et al (2021). Post‐acute COVID‐19 syndrome. Nature Medicine, 27(4), 601–615. 10.1038/s41591-021-01283-z [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Tenforde, M. W. , Kim, S. S. , Lindsell, C. J. , Rose, E. B. , Shapiro, N. I. , Files, D. C. , Gibbs, K. W. , Erickson, H. J. , Steingrub, J. S. , Smithline, H. A. , Gong, M. N. , Aboodi, M. S. , Exline, M. C. , Henning, D. J. , Wilson, J. G. , Khan, A. , Qadir, N. , Brown, S. M. , Peltan, I. D. , … Feldstein, L. R. (2020). Symptom duration and risk factors for delayed return to usual health among outpatients with COVID‐19 in a multistate health care systems network—United States, March–June 2020. MMWR. Morbidity and Mortality Weekly Report, 69, 993–998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Zhu, Z. , Lian, X. , Su, X. , Wu, W. , Marraro, G. A. , & Zeng, Y. (2020). From SARS and MERS to COVID‐19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses. Respiratory Research, 21(1), 224. 10.1186/s12931-020-01479-w [DOI] [PMC free article] [PubMed] [Google Scholar]

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