Middle cranial fossa trigeminal schwannoma resection through endoscopic transnasal maxillary sinus approach: A case report and literature review

Abstract

The endoscopic transnasal maxillary sinus approach is usually performed in resecting tumors located in the pterygopalatine fossa and infratemporal fossa, but is rarely used in the resection of lesions in the middle cranial fossa. Because of the complicated anatomical structure of the middle cranial fossa, trigeminal schwannomas (TSs) located in this region are usually dissected through conventional craniotomy surgical approaches; however, the endoscopic transnasal maxillary sinus approach can be used in resection of middle cranial fossa TSs. The current study presented the case of a 59-year-old man who suffered intermittent headaches for 2 years without other notable medical history and neurological abnormalities. The patient was diagnosed with a middle cranial fossa TS. After imaging and assessment of anatomical features, the tumor was totally resected through the transnasal maxillary sinus approach. Following surgery, the symptoms were relieved and the patient returned to a normal life. Light numbness was complained of in the distribution area of the maxillary nerve of the right side of the face, but this was gradually relieved. Combined with a literature review, the present case indicated that the endoscopic transnasal maxillary sinus approach may provide a safer and more direct option for resecting middle cranial fossa lesions, which is worthy of increased clinical application.

Introduction

Schwannomas are rare intracranial tumors that originate from Schwann cells and are rarely malignant. Trigeminal schwannomas (TSs) are the second most common type of intracranial tumor, comprising 0.2-1.0% of intracranial primary tumors and 0.8-8.0% of intracranial schwannomas (1-3). Intracranial TSs often lead to facial numbness caused by trigeminal nerve dysfunction, trigeminal neuralgia and paralysis of other cranial nerves that follows tumor compression. Notably, symptoms of TS are often related to high intracranial pressure, which can be measured by cranial radiological imaging, such as magnetic resonance imaging (MRI) and computed tomography (CT); however, pathological diagnosis is the gold standard. Histologically, schwannomas are characterized by broad interlacing ribbons of extended spindle cells that produce a palisading pattern of nuclei around a central mass of cytoplasm. Detection of S100 is required to establish the neural origin of the tumor (4). Anatomically, the majority of TSs arise from the Gasserian ganglion and spread to the intradural and epidural cavities (5). Because of the complicated anatomical structure, TSs located in the middle cranial fossa are usually dissected through conventional craniotomy surgical approaches (6). Due to the rapid development and wide application of endoscopic technology, minimally invasive endoscopic surgeries (2) and endoscopic-assisted surgeries (7) have received more attention regarding the treatment of TSs. The endoscopic transnasal maxillary sinus approach is an operation that has been used to resect tumors located in the pterygopalatine fossa (PPF) (8). Although rarely reported, this approach can also be used to resect TSs located in the middle cranial fossa (9). The present report focused on the transnasal maxillary sinus approach in dealing with lesions located in the middle cranial fossa, which is worthy of more clinical application.

Case report

Case

A 59-year-old man with a 2-year history of progressive intermittent headaches without other noteworthy medical or family history was admitted to the Department of Neurosurgery, Chongqing General Hospital (Chongqing, China) in May 2019. A neurological test showed no abnormalities. Radiography indicated that there was a spherical lesion located in the right middle fossa of the cranium with eggshell calcification (Fig. 1) that was diagnosed as a TS located in Meckel's cave. The right cavernous sinus and internal carotid artery (ICA) that were adjacent to the lesion were compressed and displaced. CT angiography (CTA) excluded vascular abnormalities.

Figure 1.

Pre-operative imaging of a TS located in the right middle cranial fossa. (A) Transverse section of the T2-weighted image indicated the position of the TS and the red arrow indicates the flow void in the ICA, which was suppressed by TS. (B) Enhanced transverse section of magnetic resonance imaging showed the direct relationship between the TS and ICA (red arrow indicates the ICA enhanced by contrast agent). (C) Transverse section of the CT scan showed the relationship among the TS, the posterior wall of the maxillary sinus and the lateral wall of the sphenoid sinus (red dotted line represents the lateral wall of the sphenoid sinus; red arrow indicates the eggshell calcification). (D) Coronal section of the CT scan showed that the TS was closely adjacent to the lateral wall of the sphenoid sinus (red dotted line represents the lateral wall of the sphenoid sinus and the red arrow indicates eggshell calcification). (E) Sagittal section of the CT scan showed that the TS was closely adjacent to the posterior wall of the maxillary sinus (red dotted line represents the posterior wall of the maxillary sinus). (F) Cerebral angiography showed that cerebral vessels were in a normal state excluding vascular abnormalities. (white dotted zone indicates the position of the tumor). CT, computed tomography; ICA, intracranial carotid artery; TS, trigeminal schwannoma.

Given that the lesion was next to the lateral wall of the sphenoid sinus and posterior wall of the maxillary sinus, the endoscopic transnasal maxillary sinus approach was chosen to mitigate operative injury as much as possible. After induction of anesthesia, the patient's head was placed in a supine position, tilted 15˚ to the right and unilateral endonasal surgery was performed. Epinephrine (1:100,000) gauzes were plugged into the right nasal cavity, thus decongesting the branches of the sphenopalatine artery. The right middle turbinate was slightly lifted and suspended. A 0˚ neuroendoscope was inserted into the middle nasal meatus and the opening of the maxillary sinus was visualized. To improve endoscopic vision, the openings of the sphenoid sinus and maxillary sinus were enlarged, and the endoscope was allowed to enter the maxillary sinus. By removing the posterior wall of the maxillary sinus and the perpendicular plate of the palatine bone, the PPF and pterygopalatine ganglion were exposed. The position of the Vidian canal opening following the Vidian nerve was determined. The Vidian nerve and artery were cut off to extend the operative space, and the foramen rotundum was exposed supra-laterally. By removing the bone of the skull base that was centered with the foramen rotundum, the TS was rapidly exposed. After being decompressed intratumorally, the tumor was completely peeled from the surrounding tissues and a piece of calcified bone slice was removed. A vertical segment of the petrous ICA was observed after the tumor was totally resected (Fig. 2). The residual cavity was compressed using a gelatin sponge to meticulously prevent hemostasis, after which, the endoscope was removed. The area covering the expanded maxillary sinus opening was resettled and the anatomical structure of the nasal cavity was reconstructed. Then, the right nostril was packed tightly.

Figure 2.

Endoscopic resection of the TS in the right middle cranial fossa through the transnasal maxillary sinus approach. (A) Endoscopic 0˚ lens entered the right meatus nasi medius and enlarged the opening of the MS (yellow dotted line indicates the edge of MS). (B) Removal of the posterior wall of MS and exposure of the PPF (yellow dotted line indicates the PPF zone). (C) Disposal of the nerves and vessels in PPF and further exposure of the opening of the Vidian canal. The yellow dotted line indicates the opening of the Vidian canal. (D) Position of the foramen rotundum was determined (yellow dotted line indicates the opening of the foramen rotundum. (E) Enlarged foramen rotundum and removal of bone from the skull base; the TS was located in the middle cranial fossa. (F) The dura was incised and the body of the tumor was exposed. (G) TS was peeled from surrounding tissues. (H) Intratumoral decompression and piecemeal resection of the tumor. (I) After the TS was totally resected, a vertical segment of the ICA was displayed. CR, clival recess; ICA, internal carotid artery; MS, maxillary sinus; PPF, pterygopalatine fossa; TS, trigeminal schwannoma.

The patient who underwent TS resection via the transnasal maxillary sinus approach experienced headache relief without cerebrospinal fluid (CSF) leakage and ocular movement function disorder. The patient complained of light numbness in the distribution area of the maxillary nerve of the right side of their face, which was gradually relieved during the follow-up. An MRI conducted 1 week after the operation showed that the TS was totally resected without destruction of the sphenoid sinus and intracranial hemorrhage. The residual cavity of the TS was covered by a layer of edema tissue that displayed a higher T2 signal caused by inflammatory responses. The anatomical structure of the brain returned to normal 3 months after the operation (Fig. 3). At the last follow-up, the TS had not relapsed. Self-healing trigeminal neuralgia and paresthesia occasionally occurred in the patient during the follow-up; however, the patient returned to normal life without other symptoms. Postoperative histological analysis illustrated that the tumor was spindle-shaped and arranged in a fence-like manner without karyomitosis, and immunohistochemical staining showed that the TS was positive for SOX-10 and S100, and negative for progesterone receptor (PR). Few cells exhibited CD34 positivity. The Ki-67 labeling index of TS was 1% (data not shown). These findings confirmed that the lesion was a cellular schwannoma that arose around the cavernous sinus (Fig. 4A-D). Written informed consent was obtained from the patient to publish this case report and the accompanying images.

Figure 3.

Post-operative imaging. A and D coronal sections, B and E transverse sections and C and F sagittal sections. (A-C) MRI scans taken 1 week after the operation, which indicated that the TS was totally resected without destruction of the sphenoid sinus and intracranial hemorrhage. The posterior wall of the maxillary sinus was removed and the residual cavity of the tumor was covered with a circle of T2 high signal intensity (red arrows indicate the T2 high signal intensity). (D-F) MRI scans taken 3 months after operation, which indicated that the TS residual cavity and the T2 high signal circle had disappeared. The anatomical structure of the brain returned to normal. MRI, magnetic resonance imaging; TS, trigeminal schwannoma.

Figure 4.

Pathological appearance of the TS and schematic diagram of the surgical range of the endoscopic transnasal maxillary sinus approach. (A and B) H&E staining of the TS illustrated that the nuclei of the tumor were spindle-shaped and arranged in a fence-like manner without karyomitosis. Individual lymphocytes could be seen in the background (white arrows indicate the lymphocytes). Scale bars, (A) 100 µm and (B) 50 µm. (C) IHC staining illustrated that the TS was positive for SOX-10. Scale bar, 100 µm. (D) IHC staining illustrated that the TS was positive for S100. Scale bar, 100 µm. (E) Schematic diagram of the surgical range of the endoscopic transnasal maxillary sinus approach. The red triangle shows the maximum extension of single-nostril surgery and the yellow triangle shows the maximum extension of two nostril surgery through 0˚ endoscopes. IHC, immunohistochemistry; TS, trigeminal schwannoma.

Pathological examination

The pathological examinations were performed by the Department of Pathology, Chongqing General Hospital. The tumor samples were fixed in room temperature with 4% formaldehyde solution for 24 h and embedded in paraffin, and were then cut into 4-µm sections for H&E staining and immunohistochemical staining. For H&E staining, the sections were deparaffinized by xylene in 60˚C for 2 h, and were stained with 0.5% hematoxylin for 3 min and 0.5% eosin for 3 min in room temperature. Subsequently, the stained sections were dehydrated and observed with a BX51 inverted fluorescence microscope (Olympus Corporation). Immunohistochemical staining of these sections was performed on a BenchMark XT (Roche Diagnostics, Inc.), which is an automatic immunohistochemical staining device. Briefly, the sections were deparaffinization in EZ prep solution (cat. no. 950-102; Ventana Medical Systems, Inc.) at 75˚C for 8 min and the antigen retrieval was performed using Cell Conditioner 1 (cat. no. 950-124; Ventana Medical Systems, Inc.) at 95˚C for 44 min. Then, the endogenous peroxides and protein were blocked by Endogenous Biotin Blocking kit (cat. no. 760-050; Ventana Medical Systems, Inc.) at 37˚C for 4 min. Following primary antibodies were used: Anti-S100 (cat. no. 760-2523; Ventana Medical Systems, Inc.), anti-SOX-10 (cat. no. 383A-78; Cell Marque, Millipore Sigma), anti-Ki-67 (cat. no. 790-4286; Ventana Medical Systems, Inc.), anti-PR (cat. no. 790-4296; Ventana Medical Systems, Inc.) and anti-CD34 (cat. no. 790-2927; Ventana Medical Systems, Inc.). All primary antibodies were prediluted by the suppliers. Primary antibodies were added and incubated for 16 min at 37˚C. Antigen-antibody reactions were visualized using OptiView Amplification kit (cat. no. 760-080; Ventana Medical Systems, Inc.) and OptiView Universal DAB Detection kit (cat. no. 860-099; Ventana Medical Systems, Inc.). All was performed in accordance with the manufacturer's protocols. Post counterstain was incubated with Bluing Reagent (cat. no. 760-2037; Ventana Medical Systems, Inc.) for 8 min at room temperature. The stained sections were observed with BX51 inverted fluorescence microscope (Olympus Corporation).

Radiological examination

The CT plain scans of coronal, sagittal, and transverse images were gathered by Siemens Emotion 16 (Siemens, Germany) with 100 kV. The CTA was gathered with 120 kV, and the data were processed and analyzed via the Siemens syngo.via software (Siemens, Germany). MRI images were obtained using a Siemens Magnetom Trio, A Tim System 3T MRI System (Siemens, Germany). T2-weighted images were obtained from a turbo spin echo sequence with a repetition time (TR) of 5,000 msec, an effective echo time (TE) of 95 msec, a field of view (FOV) of 175x230 cm, an in-plane resolution of 256x224 and a flip angle (FA) of 150. Fluid attenuated inversion recovery images were obtained from a turbo inversion recovery sequence with a TR of 8,460 msec, a TE of 134 msec, a FOV of 134x250 cm, an in-plane resolution of 250x160, and a FA of 150. The enhanced scan images were obtained from a gradient echo sequence with a TR of 204 msec, a TE of 5 msec, a FOV of 141x250 cm, an in-plane resolution of 256x154, and a FA of 150.

Literature review

To review the cases of endoscopic endonasal resection of middle cranial fossa TSs (including TS extended to adjacent fossae, such as Meckel's cave, cavernous sinus, PPF, ITF), the PubMed database (https://pubmed.ncbi.nlm.nih.gov/) was searched and available English literature that met the set requirements was screened. The following terms were searched: [‘cranial fossa, middle (MeSH)’ OR ‘meckel cave’ OR ‘cavernous sinus’] AND [‘neurilemmoma (MeSH)’ OR ‘trigeminal schwannoma’] AND (‘endoscopic’ OR ‘transnasal’ OR ‘endonasal’) and reviews, irrelevant studies (which did not report endoscopic endonasal resection of middle cranial fossa TS) and papers published in other languages (two Chinese and one Russian) were excluded.

Based on the literature review (Table I), 15 articles reporting 106 cases of middle cranial fossa schwannoma resection through endoscopic endonasal approaches were identified between 2008 and 2022 (2,9-22). Most of these cases totally dissected tumors without severe complications. The endoscopic transnasal maxillary sinus approach was used in five cases (9) and obtained great efficacy.

Table I.

Previously reported cases of endonasal endoscopic resection of middle cranial fossa TSs.

First author, year	Diagnosis	Number of cases	Location	Treatment approach	Outcome	Complications	(Refs.)
Kassam, 2009	TS	6	MCF	Expanded endoscopic endonasnal approach	Total/subtotal	V1 transient deficit/V3 numbness	(10)
Prevedello, 2010	TS	1	Meckel's cave	Endonasal endoscopic approach with Vidian transposition	Total	None	(11)
Qiuhang, 2014	TS	4	Cavernous sinus	NA	Total	None	(12)
Battaglia, 2014	Schwannoma	2	ITF	Endoscopic endonasal transpterygoid transmaxillary approach	Total	None	(13)
Raza, 2014	TS	5	Meckel's cave and PCF	Endoscopic transpterygoid approach	Total/subtotal	CN VI palsy, V1 numbness	(14)
Jacquesson, 2015	TS	1	Cavernous sinus	Endoscopic transsphenoidal approach	Total	Hypoesthesia of the maxillary nerve territory	(15)
Plzák, 2017	Schwannoma	2	PPF/ITF/MCF	Endonasal endoscopic approach	Total	V2 hypesthesia, transient trismus	(16)
Yang, 2018	TS	39	ITF/PPF/MCF/PPS/ cavernous sinus/ Meckel's cave	Endoscopic medial maxillectomy approach/ endoscopic endonasal-assisted sublabial transmaxillary approach/endoscopic endonasal-assisted sublabial transmaxillary combined with septectomy	Total	Facial numbness/facial pain/dry eyes/weakness in mastication	(17)
Jeon, 2018	TS	4	MCF/Meckel' s cave	Endoscopic transorbital approach	Total	None	(18)
Zoli, 2018	Neuroma	5	MCF/MCF and PCF	Endoscopic transmaxillary-pterygoid approach	Total/subtotal	None	(9)
Hardesty, 2018	TS	2	Meckel's cave	Transpterygoid approach	Total	None	(19)
Park, 2019	TS	25	MCF/MCF and PCF	Endoscopic endonasnal approach/endoscopic transorbital approach	Total/subtotal	None	(2)
Almomen, 2020	TS	1	ITF	Endoscopic medial and posterior walls maxillectomies	Total	None	(20)
Di Somma, 2020	TS	1	Meckel's cave	Endoscopic endonasal and transorbital surgery	Total	None	(21)
Wu, 2021	TS	8	MCF and PCF	Trans-Meckel's cave approach and transclival approach/trans-Meckel's cave approach	Total	V1-2 numbness/VI palsy/ dry eye/mastication weakness	(22)

ITF, infratemporal fossa; MCF, middle cranial fossa; PCF, posterior cranial fossa; PPF, pterygopalatine fossa; PPS, parapharyngeal space; TS, trigeminal schwannoma.

Discussion

Operations in the middle cranial fossa are challenging due to the complicated anatomical structure and vital contents. Conventional skull base surgical approaches, such as the lateral approach of the middle cranial fossa or anterior transpetrosal approach, are usually used to resect middle cranial fossa lesions but are often too invasive. Notably, these approaches could result in significant surgical complications with narrow operative corridors (23), including occlusion obstacles, temporalis muscle atrophy, facial lesions, peripheral facial paralysis and temporal lobe retraction (8), whereas endoscopic surgery has an advantage over these approaches in this regard (24). Endonasal endoscopic procedures were first used for pituitary surgery and their use has been gradually extended to other regions; in particular, these procedures are now the major approach for operating on lesions located in the skull base, including the orbit (25), parasellar space (26) and Meckel's cave (27). These surgeries provide access to a wide range of lesions by using the natural surgical corridor of the nasal cavities (28), and surgeons have more space for tumor resection and the fact that they are minimally invasive mean they are considered beneficial for surgeons and patients.

According to the present literature review, endoscopic surgery for dissecting middle cranial fossa TSs can be performed through various approaches. Notably, exploiting the optimal approach for specific lesions is important for surgeons. In the present case report, imaging demonstrated that the tumor was located in Meckel's cave, which is closely adjacent to the posterior wall of the PPF and the lateral wall sphenoid sinus. The single nostril transnasal maxillary sinus approach by two-handed surgery, which is usually used to address lesions located in the PPF (5,8), was adopted in tumor resection. It has been reported that lesions in Meckel's cave could be totally dissected through the endonasal endoscopic transpterygoid or transsphenoidal approach (19,27); however, this may damage the parasellar structures. In the present case, the specific position of the TS increased the probability of reaching the lesion through the nasal-maxillary-PPF-middle fossa corridor. The anatomical studies illustrated the advantages of the middle meatal transantral approach in dealing with lesions located in the PPF and infratemporal fossa (ITF) (29,30), revealing a new line of approach for the lateral part of the skull base (5,8). Exploiting the maxillary sinus and PPF provides a particularly short, direct surgical route to the cavernous sinus and Meckel's cave. The transnasal maxillary sinus approach is centered with PPF and reaches the anterior-lateral part of the middle cranial based on middle meatal transantral approach. Compared with conventional approaches, the transnasal maxillary sinus approach is considered safer and easier to perform due to its full exposure of the tumor at the center of the operative field and direct visualization of the ICA during tumor removal, which extends the application of the transpterygoid approach and transnasal perpendicular plate palatine bone. Compared with two-nostril surgery (operated by three or four hands), single nostril surgery can reach deeper positions and remain closer to the midline without injuring the contralateral nostril and nasal septum, even though it has to sacrifice more operative space (Fig. 4E).

The recommended application of the transnasal maxillary sinus approach is dealing with localized lesions lying on the nasal-maxillary-PPF-middle fossa axis [e.g., meningoencephalocele, schwannoma and meningioma (31)] and its adjacent area, such as the ITF and parapharyngeal space (PPS), according to our experience. As illustrated in the present case, although benign TSs are usually covered by membranes and separated from normal tissue, exposing the tumor located in the middle cranial fossa through the expanded foramen rotundum epidurally could be a reliable selection. Despite studies suggesting that endoscopic methods maximize the chances of complete resection and provide good postoperative surveillance of malignancy (32,33), the prognosis is still uncertain. For low-grade lesions, such as nasopharyngeal adenoid cystic carcinoma (34), cribriform cystadenocarcinomas (35) and smooth muscle neoplasm (36), endonasal endoscopic surgeries have been shown to acquire satisfactory efficacy due to their slow growth and weak invasiveness. Unfortunately, high-grade tumors always infiltrate the surrounding tissues, such as the brain parenchyma and vasculature, and extend to other fossae, which makes their boundaries difficult to recognize and resect completely (37). Moreover, copiously vascularized tumor tissues pose challenges. When the transnasal maxillary sinus approach is performed in the dissection of tumors located in the middle fossa, there is inadequate operative space for controlling unpredictable bleeding that may prove fatal (37). Combined approaches might be a better treatment option for malignancy, which warrants the highest chances of achieving satisfactory tumor resection with a reduced risk of complications (38). Surgeons have adopted combined endoscopic transnasal and anterior transmaxillary approaches in the dissection of nasopharyngeal carcinoma that has extended to the upper PPS (39), and have used the transmaxillary approach in combination with the endonasal endoscopic approach for giant nasoangiofibromas and chondrosarcoma (40). The absolute contraindication of such an approach has rarely been reported although there are still severe complications, including skull base reconstruction failure and intraoperative vascular lesions (38). Variations in the anatomical structure of the maxillary sinus cannot be ignored (41), because doing so would significantly influence surgical decision and complication risk.

Plans to perform an endonasal endoscopic surgery are based on complete and comprehensive evaluations, including the position, anatomical features, and pathological properties, in order to avoid making inappropriate surgical decisions. In the present case, the postoperative histological examination was in accordance with the preoperative diagnosis. It has been reported that the cells of cellular TSs are arranged predominantly in short interlacing fascicles and the nuclei are elongated with a mixture of plump and wavy nuclear morphologies (42,43), which was verified in the present case. However, atypical morphological appearance of schwannomas, such as epithelioid schwannoma, a rare variant of nerve sheath tumor, is also reported (44). Furthermore, immunohistochemical examination of S100 and SOX-10 is an effective tool for schwannoma diagnosis. It has been reported that Ki-67 labeling indices <20%, and S100, SOX-10 and neurofibromin (NF) positivity highly indicate the diagnosis of schwannoma and can exclude peripheral malignant nerve sheath tumors (45). Diffuse S100 positivity is the hallmark of all schwannomas. SOX-10 is a marker of neural crest differentiation that has also been implicated as a neural crest stem cell marker. It has previously been reported that SOX-10 has 99% specificity and S100 has 91% specificity in schwannoma (4,46,47). In the present case, common markers, such as CD34 and PR, were also tested and exhibited negativity, excluding melanoma and endothelial tumors. Some studies have also tested p16, NF (45), glial fibrillary acidic protein, epithelial membrane antigen and HMB45(43). These markers have been regarded as supplementary indices for diagnosis, which have not been widely accepted.

During the operation described in the present study, determining the position of the foramen rotundum and Vidian canal was necessary for the transnasal maxillary sinus approach to reach the middle cranial fossa. Anatomically, the maxillary nerve (CN V2) exits from the foramen rotundum traveling in the upper aspect of the PPF and joining the pterygopalatine ganglion, and then enters the infraorbital fissure. The Vidian nerve is inferomedial to V2, which is made up of greater and deep petrosal nerves (48). Identification of the Vidian nerve from the PPF can guide the surgeon to the anterior genu of the petrous ICA and can prevent the impairment of important neurovascular structures. Clinically, in the present case report, the position of the foramen rotundum was determined by locating the Vidian canal. After the opening of the Vidian canal was exposed, the Vidian nerve and artery were cut off, as the Vidian neurovascular bundle blocked the operative space for positioning and exposing the foramen rotundum. Studies have reported that when the transpterygoid approach is performed to reach the lesions in the petrous apex, Meckel's cave or cavernous sinus, Vidian nerves are usually dissected and the base of the pterygoid plates removed to reveal the petrous ICA (9,14,49).

Vidian nerves are made up of sympathetic and parasympathetic fibers, and are important for the maintenance of lacrimal function (50). However, a clinical study revealed that sacrificing the Vidian nerve during endoscopic endonasal approaches would not result in severe dry eye, although the tear volume has been shown to be reduced 1 month post-operation (51). In the present case, when the opening of the Vidian canal was identified, nerves and arteries were cut off. When the Vidian neurovascular bundle blocked the operative space for positioning and exposing the foramen rotundum, the Vidian canal remained closed intraoperatively; by cutting off the Vidian nerve, there was enough space for exposure of the foramen rotundum and to enable operating in the middle cranial fossa. The present patient did not complain of symptoms related to lacrimal function, such as a reduction in lacrimation or rhinitis, after the operation, which was in accordance with the literature. However, although such symptoms were not observed after the Vidian nerve was sacrificed, keeping it intact is important for a better long-term prognosis. An anatomical study reported that removing the bone of the Vidian canal and retracting the Vidian nerve superiorly was a method to preserve the Vidian nerve (11). Such a technique was considered more suitable for removing lesions located in a deeper position where surgeons need more operative space; however, doing so can increase surgical damage and the risk of CSF leakage.

Following tumor removal, an effective exit strategy is essential to avoid a postoperative CSF leak and its related complications (52,53). A vascularized nasoseptal flap and preoperative lumbar drainage is recommended to prevent CSF leakage (54,55). However, in the present case, preoperative lumbar drainage or an intraoperative nasoseptal flap were not prepared. The right middle turbinate was suspended during the operation, and the area covering the expanded maxillary sinus opening was resettled and the anatomical structure of the nasal cavity was reconstructed. Benefiting from the complicated dural structures, dissection of TS originating from the Gasserian ganglion and their roots would not increase the risk of CSF leakage. It has been reported that Meckel's cave is an evaginated diverticulum of the extension of the posterior fossa dura, with intricate relationships with the surrounding dural layers; however, the architectural relationship among the wall of Meckel's cave, Gasserian ganglion and roots of trigeminal nerves is still uncertain (56). It was inferred that resection of lesions limited to Meckel's cave through endonasal approaches would not lead to CSF leakage because the reflexed dura remained undamaged and the split would be covered by multiple layers of membrane structure; however, this requires further studies for verification. Notably, for tumors in a complex and deep position, cooperation with the ear-nose-throat surgical team is necessary when endonasal endoscopic surgery is performed (38). Although endonasal endoscopic surgeries are a mature technology, widely accepted and used, and have a series of operative standard in neurosurgery, otorhinolaryngologists are more familiar with the anatomical features, have proficient operative skills and rich experience in dealing with extracranial lesions and reconstruction of nasal cavities, which may improve the prognosis and self-perception of patients (57,58).

In conclusion, in the present report, a rare application of the transnasal maxillary sinus approach in the exposure and excision of TSs located in the middle cranial fossa was promoted. Compared with the conventional approach, the transnasal maxillary sinus approach is minimally invasive, provides a more intuitive and shorter route, and has excellent surgical vision and a safe operative space, which is worthy of further exploration and clinical application.

Funding Statement

Funding: No funding was received.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Authors' contributions

CX designed the study and drafted the manuscript. PW, JWW and WJF collected and analyzed the clinical data. NW performed the surgery, designed the study, critically revised the manuscript and contributed to the important intellectual content. All authors confirm the authenticity of all the raw data. All authors read and approved the final manuscript.

Ethics approval and consent to participate

All procedures were performed in in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The patient provided written informed consent to publish these features of his case, and the identity of the patient has been protected.

Patient consent for publication

Written informed consent was obtained from the patient for publication of this manuscript and any accompanying images.

Competing interests

The authors declare that they have no competing interests.