Tab. 2:
EPA test guidelines6 identified in the NanoWG survey that are relevant to ENM use cases
| EPA guideline number | EPA guideline title | Substances/products tested | References |
|---|---|---|---|
| OCSPP 870.1100 | Acute oral toxicity | Pesticides and pesticide formulations | EPA, 2002 |
| OCSPP 870.1200 | Acute dermal toxicity | Pesticides and pesticide formulations | EPA, 1998a |
| OCSPP 870.1300 | Acute inhalation toxicity | Pesticides and pesticide formulations | EPA, 1998b |
| OCSPP 870.2400 | Acute eye irritation | Pesticides and pesticide formulations | EPA, 1998c |
| OCSPP 870.2500 | Acute dermal irritation | Pesticides and pesticide formulations | EPA, 1998d |
| OCSPP 870.2600 | Skin sensitization | Pesticides and pesticide formulations | EPA, 2003 |
| OCSPP 870.3050 | Repeated dose 28-day oral toxicity study in rodents | Food additives and new dietary ingredients | EPA, 2000 |
| OCSPP 870.3100 | 90-day oral toxicity in rodents | Food additives and new dietary ingredients, pesticides and pesticide formulations | EPA, 1998e |
| OCSPP 870.3250 | Subchronic dermal toxicity 90 days | Pesticides and pesticide formulations | EPA, 1996a |
| OCSPP 870.3465 | 90-day inhalation toxicity | Pesticides and pesticide formulations | EPA, 1998f |
| OCSPP 870.3700 | Prenatal developmental toxicity study | Pesticides and pesticide formulations | EPA, 1998g |
| OCSPP 870.3800 | Reproduction and fertility effects | Pesticides and pesticide formulations | EPA, 1998h |
| OCSPP 870.4100 | Chronic toxicity | Pesticides and pesticide formulations | EPA, 1998i |
| OCSPP 870.4200 | Carcinogenicity | Pesticides and pesticide formulations | EPA, 1998j |
| OCSPP 870.5100 | Bacterial reverse mutation test | Food additives and new dietary ingredients, pesticides and pesticide formulations | EPA, 1998k |
| OCSPP 870.5300 | In vitro mammalian cell gene mutation test | Food additives and new dietary ingredients, pesticides and pesticide formulations | EPA, 1998l |
| OCSPP 870.5375 | In vitro mammalian chromosome aberration test | Pesticides and pesticide formulations | EPA, 1996b |
| OCSPP 870.5385 | In vivo mammalian cytogenetics tests: Bone marrow chromosomal analysis | Pesticides and pesticide formulations | EPA, 1998m |
| OCSPP 870.5395 | In vivo mammalian cytogenetics tests: Erythrocyte micronucleus assay | Pesticides and pesticide formulations | EPA, 1998n |
| OCSPP 870.7485 | Metabolism and pharmacokinetics | Pesticides and pesticide formulations | EPA, 1998o |
| OCSPP 870.7800 | Immunotoxicity | Pesticides and pesticide formulations | EPA, 1998p |
a
In general, the responses focused on EPA guidelines most often used to evaluate risks to human health. This table should not be considered a complete compendium of all guidelines that may be used to evaluate the effects of ENMs.