Skip to main content
Dermatology Practical & Conceptual logoLink to Dermatology Practical & Conceptual
. 2022 Apr 1;12(2):e2022053. doi: 10.5826/dpc.1202a53

Childhood Flexural Comedones

Li-wen Zhang 1, Juan Wu 2, Lu Zheng 1, Tao Chen 1,
PMCID: PMC9116544  PMID: 35646463

Case Presentation

A 20-year-old female complained of an asymptomatic papule on the left postauricular skin that occurred shortly after birth. The lesion presented a single papule with double-orifice comedones (Figure 1A). At the same site, previous skin lesion or inflammation were not observed. The dermoscopy manifested double-ended pseudo-comedones (Figure 1B). Childhood flexural comedones (CFC) with late diagnosis in adulthood was established.

Figure 1.

Figure 1

(A) A single papule with double-orifice comedones on the left postauricular skin. (B) The dermoscopy manifested double-ended pseudo-comedon.

Teaching Point

CFC usually occur in the skin folds including axilla, neck, cubital fossa, and perineum, and present as double opening comedones connected by a thin layer of the epidermis. The etiology hypotheses included potential precursors of hidradenitis suppurativa, friction, genetic background, and hamartomatous origin [1]. Histopathology showed typical open comedo with follicular plugging and infundibular dilatation [2]. Three different dermoscopic patterns of CFC have been described including cuneiform comedo, multi-orifice comedo, and double-ended pseudo-comedones [1]. The differential diagnosis includes other diseases associated with comedones, such as nevus comedonicus, acne neonatorum, familial dyskeratotic comedones, and idiopathic disseminated comedones.

Footnotes

Funding: None.

Competing interests: None.

Authorship: All authors have contributed significantly to this publication.

References

  • 1.Piccolo V, Russo T, Silva Pereira C, Darlington MD, Argenziano G. Dermoscopy of childhood flexural comedones: description of 4 cases. Int J Dermatol. 2018;57(3):e21–e23. doi: 10.1111/ijd.13894. [DOI] [PubMed] [Google Scholar]
  • 2.Larralde M, Abad ME, Munoz AS, Luna P. Childhood flexural comedones: a new entity. Arch Dermatol. 2007;143(7):909–911. doi: 10.1001/archderm.143.7.909. [DOI] [PubMed] [Google Scholar]

Articles from Dermatology Practical & Conceptual are provided here courtesy of Mattioli 1885

RESOURCES