Figure 1.

The sub-lineages of Omicron and neutralization of BA.1 and BA.2 by vaccine and Omicron serum

(A) Comparison of the mutations of Omicron BA.1, BA.1.1, and BA.2 RBDs.

(B) Position of these on the RBD (gray surface with the ACE2 footprint in dark green). Mutations common to all three are shown in white, those common to BA.1 and BA.1.1 in cyan, those unique to BA.1.1 in blue, and those unique to BA.2 in magenta. Residue 371 (yellow) is mutated in all Omicron viruses but differs between BA.1 and BA.2. The N343 glycan is shown in a transparent surface.

(C and D) Live virus neutralization. of Victoria, BA.1, BA.1.1, and BA.2 28 days following the third doses of AZD1222 (n = 41) (C), BNT162b2 (n = 20) (D).

(E) Live virus neutralization assays with VoC using sera obtained <14 days (median 13 days) and >21 days (median 38 days) following symptom onset. Geometric mean titers are shown above each column.

The Wilcoxon matched-pairs signed rank test (C and D) and Mann-Whitney test (E) were used and two-tailed P values calculated.