Table 2:

Results of Fitting a General Linear Model of Intranetwork Global Efficiency in the Frontoparietal Control Network versus Mutation Status

Variable	Estimated Effect*	Standard Error	P Value
Mutation-positive	−0.0266	0.0124	.04
EYO	−0.0005	0.0005	.32
Mutation-positive × EYO	−0.0013	0.0008	.10
Female sex	0.0048	0.0078	.54
Education (y)	−0.0007	0.0013	.59
Apolipoprotein E4 allele positivity	0.0036	0.0092	.70
Mini-Mental State Examination score	0.0022	0.0030	.46
Normalized cerebral white matter volume (% intracranial volume)	0.1126	0.2228	.62

Note.—Refer to Equation (E1) (online) for full model definition. EYO = estimated years to symptom onset.

^*The estimated effect represents the additive effect per unit rise in the variable on the global efficiency.