Table 3.
Cox regression models for the time to worsening of the PROs
| MSIS-29-Phys | MSWS-12 | HADS-Anxiety | HADS-Depression | ||
|---|---|---|---|---|---|
| Smoking status (ref: Never) | Former | 1.02 (0.88, 1.17) | 0.97 (0.84, 1.13) | 1.02 (0.88, 1.17) | 1.01 (0.88, 1.17) |
| Still | 1.3 (1.04, 1.62) | 1.16 (0.92, 1.47) | 1.25 (1, 1.57) | 1.25 (1, 1.56) | |
| PRO baseline score | 0.99 (0.99, 1) | 1 (1, 1.01) | 1 (0.99, 1.01) | 1 (0.99, 1.01) | |
| Max number of PROs | 1 (0.99, 1.01) | 1 (0.99, 1.01) | 1 (0.99, 1) | 1 (0.99, 1.01) | |
| Age at baseline (years) | 1 (1, 1.01) | 1 (0.99, 1) | 1 (1, 1.01) | 1 (1, 1.01) | |
| Gender (ref: Female) | Male | 0.97 (0.88, 1.06) | 0.96 (0.87, 1.06) | 0.98 (0.89, 1.07) | 0.98 (0.89, 1.07) |
| Time Since Onset (years) | 1 (1, 1.01) | 1 (0.99, 1) | 1 (0.99, 1) | 1 (0.99, 1) | |
| Progressive (ref: No) | Yes | 1.22 (1.09, 1.36) | 1.05 (0.94, 1.18) | 1.11 (1, 1.24) | 1.11 (1, 1.24) |
| Treatment (Ref: No treatment) | Normally active | 1 (0.91, 1.1) | 1.06 (0.96, 1.17) | 1.03 (0.94, 1.13) | 1.03 (0.94, 1.14) |
| Highly active | 1.11 (0.77, 1.62) | 1.1 (0.76, 1.6) | 1.13 (0.77, 1.64) | 1.13 (0.78, 1.65) | |
| Black, Asian, minority ethnic (ref: No) | Yes | 0.86 (0.72, 1.04) | 0.85 (0.7, 1.04) | 0.88 (0.73, 1.06) | 0.88 (0.74, 1.06) |
| Pack years | 1 (1, 1.01) | 1 (0.99, 1.01) | 1 (0.99, 1.01) | 1 (0.99, 1.01) |
Values are presented as hazard ratio (95% CI).