Figure 6.

Transient LEV treatment during sepsis acute phase dampened the post-CLP long-term behavioural impairments. (A) LEV was administrated every 12 h during the first 48 h following CLP. Long-term behaviour was then tested 15 days post-CLP. (B and C) Early LEV administration decreased the mean distance to the open field arena centre (B; n_LEV- = 26, n_LEV+ = 22, **P = 0.0055) and the freezing behaviour during fear conditioning recall in CLP surviving mice (C; n_LEV = 17, n_LEV+ = 14, Auditory: **P = 0.0024). LEV data in B and C are pooled with CLP data from Fig. 1. Statistics: (B and C) Mann–Whitney test or unpaired t-test. Data shown as mean ± SD.