The Management of Scabies in the 21st Century: Past, Advances and Potentials

Abstract

Scabies is one of the most common skin diseases worldwide, affecting 150–200 million people yearly. Scabies affects young children in particular, and has the greatest impact in poor overcrowded living conditions. The burden of the disease is now well characterized, including group A Streptococcus and Staphylococcus aureus bacterial superinfections, with reports of nephritis, acute rheumatic fever, or fatal invasive sepsis secondary to scabies. Management of scabies remains largely suboptimal from diagnosis to treatment, and progress in the development of new therapeutic measures leading to cure is urgently needed. This review gives an overview of the current limitations in the management of scabies, an update on recent advances, and outlines prospects for potential improvements.

Scabies (Latin scabere “ to scratch”) is a common parasitic disease caused by the microscopic mite Sarcoptes scabiei var. hominis (1). The burrowing mite causes intense itching, associated with typical skin lesions. The disease has been known for over 2,500 years; the Greeks and Romans were the first to write about its contagious nature. The mite was first identified and illustrated in the 17^th century (2). Despite marked advances in parasitology in the 19^th and 20^th centuries, research into scabies has been hampered largely by limited access to the parasite and by low interest in an ectoparasite that mainly affects the poor. The earliest understanding of the mite biology and transmission was provided by Kenneth Mellanby, a British entomologist, in the 1940s during World War II (3, 4). Further advances in the physiopathology and host-parasite interactions have been made in the last 30 years (5, 6), mainly through the development of experimental animal models (7, 8). The therapeutic options for the management of scabies increased considerably in the 1970–80s with the discovery of ivermectin, one of the most important drugs currently used to treat scabies; the researchers were recently awarded, 35 years after its discovery, the 2015 Nobel Prize for Physiology and Medicine (9).

SIGNIFICANCE

Scabies is more than just a disease that provokes a horrendous itch. For more than a century, researchers, clinicians and public health physicians, together with policymakers, have worked to improve the management of scabies. Finally, in 2017, scabies was added to the WHO list of neglected tropical diseases after a long and still ongoing process of documenting the morbidities and burden caused by the disease. This additional and increased research activity, resulting in high-impact publications, has increased our knowledge of the biology, pathology and management of scabies, and has opened doors to new strategies.

Currently, the recent expansion of multi-omics techniques will enable scientists to design large-scale mite and host molecular and biochemical analyses to develop new diagnostic tools or treatments in the near future (10–13). Scabies was, for a long time, not appropriately considered to be a true health target. In the past 10 years, stupendous efforts, made by a group of experts brought together in the International Alliance for the Control of Scabies (IACS), have given scabies the recognition it deserves (14). Thus, in 2017, the WHO decided to add scabies to the list of neglected tropical diseases and has called for large-scale action to achieve control and eradication (15).

WHY DO WE NEED TO IMPROVE SCABIES TREATMENT?

Scabies is a prevalent disease, which is present in all parts of the world, with greatest prominence in disadvantaged populations living in tropical and subtropical regions, and has a documented significant burden. The latest estimates suggest that 150–200 million people have scabies in the world every year, and that the scabies burden is particularly high in Asia, Oceania, and Latin America (16). Young children in underprivileged populations living in crowded conditions are more often at risk (17). Transmission of scabies occurs mainly via skin-to-skin contact and, less frequently, via fomites within a patient mite-contaminated environment (generally in the context of severe forms of scabies; see below). As scabies is contagious, persons sharing the same household with patients may frequently be affected. This is especially the case in severe scabies, i.e. profuse or crusted scabies, in which the mite burden per person is dramatically increased, small epidemics around a single case can easily develop, and are fuelled by overcrowded households and transient lifestyles. The risk of transmission is known to depend on the patient’s mite load, household size and population concentration, and how individuals interact with each other. Indeed, people living in clustered communities or in crowded housing conditions are at higher risk of scabies and outbreaks. In high-income nations, high endemicity of scabies is often reported in closed communities and institutional settings, such as hospitals, child-care and elderly-care residential facilities (18, 19), prisons, schools, homeless populations, and refugee camps (20–22).

For a long time, the scabies mite has been erroneously perceived as an ectoparasite that just causes itching. However, recent epidemiological studies indicate increasingly substantial morbidity, and even mortality (23), due to scabies infection, mostly caused by bacterial infections appearing with the parasitic infestation (14, 24). It has been hypothesized that scratching of lesions in response to the immense itch is present more often in scabies than in any other pruritic skin affections (25). The discomfort caused by the intense itch can have direct consequences, i.e. depriving patients of sleep (26), interfering with concentration at work or school, leading to a negative impact on attendance, performance (27) and quality of life (28). Scratching scabies lesions themselves leads to breaches in skin barrier that creates an entry point for opportunistic commensal or pathogenic bacteria that can become invasive, such as group A Streptococcus (GAS) and S. aureus (29). These bacteria lead to secondary infection of the epidermis, also known as pyoderma or impetigo, which can become more severe and cause skin and soft-tissue infections (including necrotizing fasciitis), septicaemia, or more invasive bacterial infections (24). In some cases, immune-mediated diseases can occur following infection, such as glomerulonephritis (30) or acute rheumatic fever (31), both of which can become chronic. This association between scabies parasites and bacterial pathogens is observed mainly in tropical or subtropical areas of the globe and in remote locations (17); with some data suggesting that up to 40% of impetigo lesions can be linked with scabies, especially among young children (32, 33). This particular link was established early in the 1970s, with epidemiological studies showing epidemics of acute glomerulonephritis in Trinidad (34) or Southern Africa (35) contemporaneously with scabies outbreaks, or in interventional studies in the field showing reduction in childhood haematuria following scabies treatment (30), or reduction in impetigo or skin sores prevalence paralleling a reduction in scabies numbers during mass drug administration (MDA) campaigns (36–38). More recent fundamental experimental work has supported and, in part, explained these observations with evidence of direct effects of mite gut proteins (serpins and serine proteases) in downregulating the innate host immunity including complement defence and neutrophil function, thereby modulating the microenvironment around the mite, allowing associated bacteria to flourish (39–43). Beyond the itch, scabies still causes a significant social impact, affecting quality of life and school or job absenteeism amongst infested patients. Its marked social, economic and psychological ramifications are underscored, but are sufficient to justify global improvement in its management.

WHO DO WE NEED TO TREAT?

Typically, the first symptoms of scabies are severe itch that worsens at night (44) and typical skin lesions caused by the penetration and progress of the mite through the epidermis. Most scabies lesions are found in classical sites, such as finger webs, hands, wrists, periumbilical skin, buttocks, genitals, periareolar region in females, or feet (1). In adult patients, the head is usually not affected, although it may be involved in infants, and babies (45). Burrows, vesicles, pustules, nodules, or excoriated pruritic papules are the most common lesions observed, all of which indicate the presence of a mite within the epidermis (Fig. 1A). The severe forms of scabies include profuse and crusted scabies. Both presentations are characterized by a very high parasite burden, with hundreds, thousands or even millions of mites per patient, and the development of extensive lesions. In such forms of scabies, hyperkeratotic skin (rather than real crusts) may be restricted to a finger, toe, or the scalp, for example, or diffusely affect multiple skin sites, including the face and palms and soles (1). This condition is seen in the elderly or in patients with underlying immunodeficiency from any cause (transplant recipients, corticosteroid use including topically-applied medication, HIV-, or HTLV-1-infested patients) (46–48).

Fig. 1.

Typical lesions of ordinary scabies. (A) Scabies lesions on the palm of the right hand with linear burrows, tiny vesicles and papular scabies lesions. (B) A burrow lesion from patient in (A) using dermoscopy showing the “jet-with-contrail” and an image of a brown triangle at the end, the “deltawing jet” (10-fold magnification). (C) Direct examination of skin scraping from patient in (A), showing an adult scabies mite (x10, lactophenol cotton blue staining).

The diagnosis of scabies is easy if a burrow, the specific lesion of scabies, is observed at a typical site of predilection. However, burrows may not be visible and diagnosis of scabies can be challenging, leading to misdiagnosis and mismanagement. Clinical diagnostic algorithms have been created to assist health-workers in recognizing scabies using a combination of parameters of patient history and clinical arguments, such as, for example, a history of diffuse itch, presence of lesions in typical skin areas, and itching in household members (49, 50). These diagnostic aids, which have proved reliable in endemic regions, have to be extrapolated and optimized across a larger range of settings, from the dermatologist’s daily practice offices to resource-poor field settings, regardless of local prevalence. With this in mind, consensus criteria for the diagnosis of scabies were developed recently using a 4-round Delphi process including 34 international experts under the aegis of IACS (51). The IACS 2019 Criteria includes 3 levels of definition (confirmed scabies, clinical scabies, and suspected scabies case) and 8 subcategories. The accuracy and reproducibility of scabies diagnosis using these criteria have yet to be validated, as well as the ease of using it for GPs, experts in dermatology and other specialties, and non-expert health-workers (52).

As yet, a simple test for scabies based on molecular markers is still not available. Non-invasive methods have been developed for directly identifying the mite in diagnostic scrapings (53). The gold standard remains the visualization of the parasite (adults or immature forms), eggs, eggshell fragments or mite faecal pellets by light microscopic examination of a skin scraping. New technologies have been customized. Their sensitivity and specificity are summarized in Table I. Light microscopy examination has an excellent specificity (Fig. 1B), but is highly operator-dependent and is time-consuming, as repeated scrapings may be necessary. Dermoscopy or epiluminescence microscopy are tools used in daily clinical practice by dermatologists for a variety of cutaneous disorders, including parasitic infestations (54). The diagnosis of scabies using dermoscopy is confirmed by the observation of the “jet-with-contrail” pattern in the skin, representing a mite and its burrow, or an image of a black or brown triangle, the “delta-wing jet” sign representing the head of the mite (Fig. 1C) (55). Videodermatoscopy utilizes a dermoscope with a video camera connected to a computer that allows very high magnification and can be used to assess the viability of living mites. These are expensive techniques and therefore some authors have adapted low-cost equipment, used in botanical or entomology investigation, for use in the medical assessment of scabies (56). Reflectance confocal microscopy has been developed more recently for pigmented skin lesions, to differentiate malignant melanoma from benign naevi. The system uses an 830nm wavelength diode laser and provides high optical resolution to penetrate to a depth of 200–300 μm into the skin. Imaging of the scabies mites and eggs using this device has been described (57). Some authors have tried to develop diagnostic techniques using molecular tools, such as matrix-assisted laser desorption ionization – time of flight (MALDI-TOF), antigen detection system or PCR specifically targeting scabies DNA. With PCR, while most studies have found a very high specificity, often close to 100%, sensitivity was continually low, ranging from 30% to 60% (58–60), poorer compared with parasite observation either by microscopic or dermoscopic examination (61). No biomarker-based diagnostic kits have been developed for use as a simple and rapid method to identify mite infection without dermatological skills.

Table I.

Comparison of the specificity and sensitivity of the different currently available diagnostic non-invasive methods for scabies. Adapted from Chosidow & Sbidian (62) and Micali et al. (53)

	Clinical diagnosis algorithm	Skin scraping and light microscopy	Burrow ink test	Adhesive tape test	Epiluminescence microscopy (dermoscopy)	Videodermatoscope	Reflectance confocal microscopy	PCR-based method
References	(49)	(55)/(63)	(64)	(63)	(55)/(63)	(65)	(65)	(59)/(66)
Sensitivity, %	96.2	90/46	36.6	68	91/83	95	92	75.7/37.9
Specificity, %	98	100/100	100	100	86/46	97	100	100/100
Positive predictive value, %	87.7	100/100	–	100	88/47	97	100	–/100
Negative predictive value, %	99.4	90/77	–	85	90/85	95	92	–/61.7
Duration of the procedure	15 min for the entire body	30 min	5 min	10 min	5–10 min for the entire body	5–10 min for the entire body	60 s to 10 min for each lesion	Half a day
Prices, USD	–	US$ 500	–	US$ 10	US$ 500–700	US$ 25,000	US$ 150,000	US$ 200

Improvement in scabies management is essential and will come from better identification of which patients need to be treated. Thus, the accurate and definitive diagnosis of scabies is crucial. Non-invasive diagnostic tools have been developed, but will have to be improved further.

HOW CAN WE TREAT SCABIES?

Treatment of small clusters (individual and family level)

Treatment must be prescribed for all confirmed cases of scabies, and should be given to all household and family contacts. The options available for treatment of scabies are summarized in Table II. Topical medicines were considered first-line treatment until the arrival of oral ivermectin in 1981, which was, at first, reserved for recurrent, difficult-to-treat cases, those with superinfected or eczematous skin, or for patients with crusted scabies (67). Topical agents should be applied to the entire skin surface, from “head-to-toe”, avoiding the eyes, nose, and mouth. The application period depends on the specific instructions from the manufacturer. Adverse events are reported with all topical medicines for scabies, but they appear to be limited. Oral ivermectin is given at a standard dose of 0.2 mg/kg and may be associated with lower rates of complete cure if given only once (68–70). This could be explained by the limited ovicidal activity of the drug (71) and the short half-life of ivermectin in the skin, which was shown in 2 experimental trials in a porcine scabies model (72, 73). Giving the drug with a high-fat content meal has been proposed in order to increase its absorption and, accordingly, this might increase its efficacy (74, 75). Most scabicides act by affecting the nerve and muscle function of the parasite, and they are active only against mobile stages (larva, nymph and adults) and not eggs (13). The optimal interval between dosing in the 2-dose regimen still needs to be optimized and should be a short window between larval hatching (occurring at day 2–4 of the mite life-cycle) and the development of the adult stage that can be fertilized (at day 5–8, maximum day 15). Two recent Cochrane systematic reviews of data from respectively 22 (76) and 15 (77) randomized controlled trials (RCTs) placed topical 5% permethrin and ivermectin at the same level of efficacy and safety, and are consequently considered as the reference treatments. Between these 2 systematic reviews, performed in 2010 and 2017, no newer trials were included in the evaluation, but the conclusions were different based on the regimen of the drugs used. Strong & Johnstone (76) concluded, in 2010, that topical permethrin 5% was the most efficacious agent for the treatment of scabies. Rosumeck et al. in 2017 (77), reviewing the same trials as in 2010, concluded that topical permethrin was equal to ivermectin when 2 doses were given. Overall, among all the therapeutic trials analysed, a significant heterogeneity in the methods and outcome measurements was found, making the conclusions difficult to evaluate. A French randomized clinical trial, cluster-designed with a robust protocol, is currently recruiting patients with common scabies to establish finally which treatment, 5% topical permethrin or 0.2 mg/kg oral ivermectin, both given twice at 10 days’ interval is the most efficacious (SCRATCH, NCT02407782) (78). Treatment also depends on the availability of the drug in the different countries. For example, since it was first approved in France for the treatment of scabies in 2001, oral ivermectin has been licensed only for this indication in 10 nations as first-line treatment, and is mostly used off-label and may not even be accessible in other countries. In those countries, available and cheaper medications are preferred, such as sulphur preparations and benzyl benzoate. To widen access to this key effective medication, in June 2019 the WHO added ivermectin to the 21^st WHO Essential Medicines List (79).

Table II.

Comparison of treatments in use to treat scabies in humans

Drugs	Formulations	Recommended treatments	Cost (Euros)	Efficacies (%)*	Main adverse reactions	Use in children	Use during pregnancy	Use in breastfeeding women
Ivermectin	200 μg/kg Pills	Repeat after 7 days	€19 for 4 tablets at 3 mg=€38 for a complete treatment (weight 70 kg)	70–100	Nausea, rash, dizziness, itching, eosinophilia, abdominal pain, fever, tachycardia	Not approved in children <15 kg or 5 years of age	Only recommended in France	Only recommended in France
	1% Cream/lotion	Overnight (8–12 h) – from head-to-toe – repeat once after 7–14 days	€20 for 15 g cream=€80 for a complete treatment	69–85	Pruritus, burning, stinging, eczema	Not approved in children	Not recommended	Not recommended
Permethrin	5% Cream	Overnight – from head-to-toe – repeat once after 7–14 days	€19 for 30g cream=€38 for a complete treatment	86–100	Pruritus, burning, stinging, eczema	Safe in children ≥2 months of age	Approved	Not recommended
Benzyl benzoate	10–25% Lotion or emulsion	Apply from head-to-toe for 24 h On days 1, 2 and repeat after 7 days	€15 for 125 mL emulsion=€30 for a complete treatment	48–92	Pruritus, burning, stinging, pustules, skin irritation, eczema	Safe in children ≥ 1 month of age	Authorized if necessary	Not recommended
Crotamiton	10% Cream	Overnight on days 1 and 2	€7 for 40g cream	63–88	Pruritus, skin irritation, eczema, erythema, anaphylactic reaction	Safe in children	Not recommended	Not recommended
Precipitated sulphur	6–33% Cream or lotion	Apply from head-to-toe for 3 consecutive nights	–	39–100	Messy application, malodour	Safe in children	Authorized	–
Malathion	0.5% Aqueous lotion	Repeat after 7 days	€12 for 100 ml=€24 for a complete treatment	47–72	Pruritus, burning, stinging, skin irritation, CNS toxicity, dizziness, seizure	Not approved in children <2 years of age	Withdrawn from the European market	Withdrawn from the European market
Lindane	1% Lotion or cream	Overnight Repeat after 7 days	–	64–96	CNS toxicity, dizziness, seizures, renal and hepatic toxicity reported with overdosage	Withdrawn from the European market	Withdrawn from the European market	Withdrawn from the European market

^*Efficacies according to Strong & Johnstone (76). Updated from Bernigaud C. et al. (13).

CNS: central nervous system.

Follow-up is necessary after treatment, to evaluate the cure of the patient and to prevent re-infestation. Treatment success should be expected in approximately two weeks. Itching can persist for up to one month after successful treatment. Causes of apparent treatment failure with an effective treatment include incorrect diagnosis, dermatitis secondary to the mite or topical agent, incorrect application of the topical agent, poor penetration of the agent into hyperkeratotic skin or nails, and re-infestation from scabies-infested close contacts (80). Parasite resistance has been reported for both permethrin (81, 82) and ivermectin (83, 84), but its clinical importance remains a matter of debate. Studies are lacking and surveillance for better documentation is warranted. Treatment failure has been observed, mainly because drugs are not 100% effective (74– 93% clearance is observed with permethrin and 68–86% with ivermectin (77)). Some authors recently tried to determine which factors were associated with treatment failure (85, 86). These 2 studies found that incorrect decontamination of furniture or fomites was a key factor in treatment failure. While living mites can be found in samples of environmental dust from floors and furniture of patients with scabies (87), the indirect transmission of mites by fomites is thought to be rare (3), at least in common scabies. Studies are needed to evaluate the impact of environment-decontamination procedures on the success of the treatment (88) in non-profuse cases of scabies and in cases of severe scabies with high mite-load, in order to optimize cure rates. Simplified and generalized algorithms, based on high-throughput experimental data that can be used in a large range of settings, including resource-poor population, were suggested recently (89).

Appropriate treatment should also be given for severe secondary bacterial infection. Topical antibiotic creams (e.g. mupirocin or fusidic acid) are not recommended in cases with profuse lesions. Systemic antibiotics have to target GAS and S. aureus (including MRSA in specific areas). Oral trimethoprim-sulphamethoxazole (cotrimoxazole) or intramuscular benzathine penicillin G are used in tropical endemic regions (90), whereas pristinamycin, amoxicillin/clavulanic acid or cephalexin may be used in non-tropical regions. For the itch, there is no specific treatment. Antihistamines can assist, but it is their sedative properties that are effective, rather than an anti-pruritic mechanism (91).

For the treatment of crusted scabies, there is no consensus as, to date, no randomized controlled trials have been performed. Most records come from small studies, and experience in northern Australia, where highly infested patients are seen (47). They suggest a regimen of multiple doses of oral ivermectin with repeated topical permethrin and keratolytic therapy.

For the treatment of children, only topical treatments have been approved. The application time in children can differ from that in adults. Oral ivermectin cannot be used if the patient’s body weight is less than 15 kg. Recent reports using ivermectin off-label in infants and young children (aged 1–64 months, body weight 4–14.5 kg) are highly reassuring on the safety and efficacy of this treatment in this age group (92). Recommendations for use of ivermectin in infants may change in the near future. For the treatment of pregnant women, only one country allows the use of ivermectin, as a second-line treatment after 5% topical permethrin, at any trimester of the pregnancy supported by an expert recommendation (93). Most exclusions of women from ivermectin treatment are for basic precaution rather than any anticipated foetal toxicity. In practice, thousands of women have been treated inadvertently before their pregnancy becomes known in onchocerciasis eradication programmes in Africa. Occurrence of miscarriage, stillbirth, or birth defects in the reference population did not differ significantly (94, 95). Continued surveillance is necessary, as well as more fundamental work to enable this target population to be treated adequately.

Treatment of large clusters (collectivity level)

As scabies is a contagious disease spread by skin-to-skin contact, people living in crowded communities are at greater risk. In these collectivity settings, because patients and their close contacts have to be treated all at the same time and because prevalence can be very high in some communities, the opportunity of MDA has emerged to control scabies in endemic spaces (96). The first MDA was performed in a scabies-endemic region of Panama in the 1970s by Taplin et al. (97). Successively, multiple programmes have evolved in all parts of the world to control scabies by MDA, firstly with lindane, topical permethrin, followed by the use of oral ivermectin (summarized in Table SI¹). Only one trial, the Skin Health Intervention Fiji Trial (SHIFT) has randomized 3 islands in Fiji to 1 of 2 intervention strategies, i.e. oral ivermectin and topical permethrin, compared with standard care as control (36). At 12 months, mass treatment with ivermectin was found to be the most effective, with a relative reduction of 94% from baseline in the prevalence of scabies and 67% in impetigo. During all these years, many MDA programmes have resulted in successful and significant reduction in the prevalence of scabies in highly endemic or endemic settings. Controversial results have been reported only from Australia (see Table SI¹), presumably because the adherence of the target population with the treatment regimen was poor. Fewer data exist on the sustainability of success of MDA in the longer term, but this approach seems to be efficient (98, 99), especially in communities with a scabies prevalence higher than 5% (100). Interestingly, the treatment of scabies alone also seems to result in a significant reduction in GAS impetigo (36) and kidney complications, signified by the reduction in haematuria (30). A recent study has indicated that it is not necessary to add antibiotics during MDA for scabies to reduce the prevalence of impetigo (37). Although, as most MDAs target only one disease, some programmes have looked at the potential to integrate scabies MDA in other schemes for neglected tropical diseases eradication programmes (101), such as onchocerciasis, lymphatic filariasis, trachoma, schistosomiasis, yaws, or infection with soil-transmitted helminths. On a smaller scale, combining ivermectin and albendazole administration to treat both lymphatic filariasis and onchocerciasis, or scabies and lymphatic filariasis (102), or scabies and strongyloidiasis (103) were found to be effective and safe. On a larger scale, the co-administration of azithromycin and ivermectin for targeting trachoma and scabies in the Choiseul Province, Solomon Islands, was also found to be effective, feasible and secure in 26,188 enrolled participants (104). Remarkably, MDAs for scabies control have had additional unintended downstream effects, as they have been found to be efficient in controlling head lice (105) and Anopheles farauti, the vector of malaria in the Solomon Islands (106). All these interesting programmes provide positive results and robust evidence to encourage MDA with ivermectin to control scabies in highly endemic populations on a larger scale. Optimization of these programmes will be required in order to understand factors associated with success, defining the appropriate regimen to use, and determining the numbers of rounds of MDA (24).

Similarly, controlling scabies at a larger scale by MDAs has been extrapolated for smaller outbreaks in closed institutions, such as schools (107), prisons (108), age-care facilities (18), and, more recently, in asylum seekers (109).

HOW WILL WE TREAT SCABIES IN THE NEAR FUTURE?

As mentioned above, treatment either with a topical acaricide or oral treatment with ivermectin are the current standards of care for common scabies. Most patients with scabies infection will recover with a suitable medical intervention, but patients often require multiple treatments and/or a combination of topical and systemic drugs. The major limitations of current therapies are poor compliance with repeated treatments, limited activity against eggs, and half-lives too short to cover the whole 14-day life cycle of the mite (13). The recent development of an experimental porcine scabies model provides real potential to conduct translational preclinical and pharmacokinetic studies with new drug candidates.

In order to optimize and improve the therapeutic options for scabies treatment, the concept of translating existing drugs used in the veterinary clinic to humans was investigated (72, 73). Moxidectin is a molecule compound suitable for oral administration. It is a member of the same family as ivermectin, and was recently developed and approved by the US Food and Drug Administration (FDA) for treatment of onchocerciasis. Moxidectin has a very interesting pharmacological profile: rapid absorption, large distribution, and a much longer half-life in plasma and, importantly, in the skin than ivermectin (72), potentially covering the entire life-cycle of the scabies mite. In a pilot trial in the experimental pig model for scabies performed in France, moxidectin used orally, at a single dose of 0.3 mg/kg, was found to be more effective than the conventional 2 doses of ivermectin at 1-week interval (0.2 mg/kg) (72). A multicentre clinical phase II trial in humans is in progress in Australia and France, with the aim of developing moxidectin as a new single-dose treatment for scabies (NCT03905265) (117).

The use of higher doses of ivermectin for treatment of scabies is also an interesting option and currently under investigation (118). The clinical development of ivermectin for scabies and other parasites might have been rushed, and the dose of 0.2 mg/kg was not derived after high-level dose-ranging studies; it was based on a reasoned, but arbitrary, decision. An emerging hypothesis is that the parasite infection may need a higher dose of ivermectin to achieve a cure. This concept was first raised for head lice infestation, as the standard dose of oral ivermectin (0.2 mg per kg body weight) was found to be poorly effective. Further studies found that treatment with 0.4 mg/kg ivermectin (a double dose) was approximately 95–100% effective (119). Similar results were reported for other parasitic infections (118). Dose-ranging experimental studies in the pig model are ongoing to determine whether higher doses of ivermectin are more effective at controlling scabies infestation. In France, a French Ministry of Health-approved randomized controlled clinical trial is in process, comparing the efficacy of ivermectin given orally as the higher double dose of 0.4 mg/kg with the conventional treatment dose of 0.2 mg/kg, given 3 times 7 days apart (on D0, D7 and D14), supplemented in both arms with daily application of emollient therapy and topical 5% permethrin on D0 and D7 (GALECRUSTED, NCT02841215) (120).

Other novel treatments are also in development, using herbal compounds (121, 122) and even entomopathogenic fungus (123). The use of advanced molecular and biochemical technologies will help to design new therapeutic tools. These next-generation drugs are needed immediately and should be tailored to scabies mites.

CONCLUSION

The worldwide prevalence of scabies remains high, and currently available treatments may not be sufficiently effective to control the disease. During the past 20 years, at the beginning of the 21st century, a lot of important work has been completed concerning the management of scabies, mainly driven by IACS, a global advocacy body formed in 2012. We hope that the next 10 years will provide a significant improvement for patients infested with scabies, and that new drugs and diagnostics will enhance the therapeutic options for the benefit of patients and their families.