Figure 5.

Functional analysis of the 50 top up-regulated lncRNAs by SARS-CoV-2 infection considering their validated interactions with RNA-binding proteins retrieved from ENCORI database ⁴². A, GO-term enrichment analysis for biological processes of the RNA-binding proteins that interact with the selected overexpressed lncRNAs in SARS-CoV-2 patients with high viral loads; B, pathway enrichment analysis using the KEGG database and considering the RNA-binding proteins that interact with the selected overexpressed lncRNAs in SARS-CoV-2 patients with high viral loads; C, interaction map between RNA-binding proteins and the 50 top overexpressed lncRNAs in SARS-CoV-2 patients with high viral loads. The number of interactions is depicted as circles with a diameter proportional to the number of RNA-binding sites in each lncRNA. The right-hand side panel represents the density of RBP binding sites per 1000 nucleotides in each lncRNA as extracted from the ENCORI database.