Appendix 1—figure 2. The diagram shows a schematic description of the number of genes and GCs that have been kept or discarded.

(A) We analyzed a dataset of 1749 metagenomes from marine and human environments and 28,941 genomes from the GTDB_r86 summing up to 415,971,742 genes. The composition of the genomic box ‘Other’ is described in Appendix Note 5. (B) GC overlap between the environmental and genomic datasets.