Appendix 3—table 3. Steps: Step I - Removing of the "bad clusters".

Step II - Removing of the "shadow clusters". Step III - Removing single spurious, shadow or outlier genes.

(A) Number of clusters in each step of the cluster refinement.
	Step I	Step II	Step III	Refined
Clusters	3,003,897	2,946,845	2,940,593	2,940,257
Removed	–57,052	–6,252	–336
(B) Number of genes in each step of the cluster refinement.
	Step I	Step II	Step III	Refined
Genes	268,467,763	263,022,636	262,851,348	260,142,354
Removed	–5,445,127	–171,288	–2,708,994