Table 2:
Linear Regression β Coefficients for the Association of VSQOL IRT Composite Scores and VFL in the MOCCaS (n = 14,570)*
| Vision-Specific Quality of Life Item Response Theory | ßMD | (95% CI) | MD (dB) of VFL for 5-point of VSQOL† | P-Valuei‡ | ||
|---|---|---|---|---|---|---|
|
| ||||||
| Latinos | Chinese Americans | African Americans | ||||
|
| ||||||
| Task Composite, IRT§ | ||||||
| Latinos | 0.750 | (0.646, 0.854) | 6.7 | < 0.001 | ||
| Chinese Americans | 0.719 | (0.567, 0.872) | 7.0 | 1.000 | < 0.001 | |
| African Americans | 0.496 | (0.374, 0.617) | 10.1 | 0.004 | 0.172 | <0.001 |
| Well-Being Composite, IRT|| | ||||||
| Latinos | 0.666 | (0.560, 0.772) | 7.5 | < 0.001 | ||
| Chinese Americans | 0.575 | (0.419, 0.731) | 8.7 | 0.990 | < 0.001 | |
| African Americans | 0.387 | (0.263, 0.511) | 12.9 | 0.002 | 0.420 | < 0.001 |
VSQOL = Vision-Specific Quality of Life; VFL = Visual Field Loss in the better seeing eye;
MOCCaS = Multiethnic Ophthalmology Cohorts of California Study; 95% CI = 95% confidence interval; NEI-VFQ-25 = National Eye Institute Visual Function Questionnaire 25-Item; MD = Mean Deviation; IRT = Item Response Theory
VFL is presented as mean deviation score in decibels; VSQOL is assessed by IRT analysis of the NEI-VFQ-25. Linear regression models of VSQOL on VFL were adjusted for race/ethnicity, age, number of comorbidities, sex (female), born in USA (yes), education highest grade obtained), working status (unemployed), income (≤ $20,000), has health insurance (yes), presenting binocular visual acuity (LogMAR score), depression (a good bit of the time or more in the last 4 weeks), and an interaction between VFL and race/ethnicity.
Regression coefficients were transformed per 5-point difference in HRQOL score, a clinically significant difference in VSQOL score.
P-values along the diagonal represent main effects for associations between VSQOL and VFL within each racial/ethnic cohort; P-values off the diagonal indicate interactions across cohorts. The Holm method was used to adjust for multiple comparisons for 15 VSQOL outcomes.
IRT Task Composite was calculated from a graded response theory model of 12 items from near vision, distance vision, driving, color vision, peripheral vision, and role difficulties subscales.
IRT Well-Being Composite was calculated from a graded response model of 12 items from general vision, dependency on others, mental health, ocular pain, and social functioning subscales.