Table 2:
Cardiac Structure, Function, and Hemodynamics at Baseline
| Cardiac Structure and Function | No PVD (Exercise PVR<1.74) (n=382) |
Latent PVD (Exercise PVR≥1.74) (n=188) |
p |
|---|---|---|---|
| LVEF (%) | 60±8 | 59±8 | 0.200 |
| LA volume index (ml/m2) | 34±13 (347) | 35±17 (172) | 0.270 |
| Septal E/e’ ratio | 15.1±6.7 (343) | 17.6±8.3 (161) | 0.001 |
| Mitral regurgitation (trace/mild/mod %) | 49/43/8 | 41/47/12 | 0.093 |
| TAPSE (cm) | 2.1±0.4 (339) | 1.9±0.4 (157) | <.001 |
| RV volume index (ml/m2) | 23±9 (276) | 25±11 (117) | 0.063 |
| RA volume index (ml/m2) | 27±12 (314) | 31±15 (145) | 0.003 |
| Resting Hemodynamics | |||
| Heart rate (bpm) | 72±13 (381) | 71±12 (188) | 0.688 |
| Systolic blood pressure (mmHg) | 141±25 (360) | 146±29 (174) | 0.046 |
| RA pressure (mmHg) | 9±4 (378) | 10±4 (187) | 0.026 |
| PA mean pressure (mmHg) | 25±7 (375) | 31±8 (187) | <.001 |
| PA wedge pressure (mmHg) | 18±7 (375) | 20±6 (187) | 0.001 |
| Cardiac output (l/min) | 5.7±2.2 (366) | 5.0±1.3 (185) | <.001 |
| Pulmonary vascular resistance (WU) | 1.4±0.6 (370) | 2.3±0.9 (185) | <.001 |
| Peak Exercise Hemodynamics | |||
| Heart rate (bpm) | 101±22 (381) | 102±24 (185) | 0.622 |
| Systolic blood pressure (mmHg) | 158±34 (339) | 165±34 (168) | 0.036 |
| RA pressure (mmHg) | 18±5 (379) | 20±7 (186) | <.001 |
| PA mean pressure (mmHg) | 44±8 (382) | 52±10 (188) | <.001 |
| PA wedge pressure (mmHg) | 35±8 (382) | 35±9 (188) | 0.672 |
| Cardiac output (l/min) | 9.1±2.8 (382) | 7.1±2.3 (188) | <.001 |
| Pulmonary vascular resistance (WU) | 0.98±0.43 (382) | 2.76±0.82 (188) | <.001 |