Figure 4. Compensatory mechanisms preventing aggregation and imbalances in complexes partly explain abundance changes on other chromosomes.

Protein abundance correlations between differentially abundant proteins on aneuploid chromosomes and their co-complex members on other chromosomes when aneuploid proteins are grouped as (A) aggregation-prone and non-aggregation-prone and (B) promiscuous and non-promiscuous. (C) Co-occurrence frequency of differentially abundant proteins on aneuploid chromosomes and their co-complex members on other chromosomes in different correlation groups, positively and negatively correlated and non-correlated co-complex members of aneuploid proteins. Wilcoxon test was used to test the differences between groups.

Figure 4—figure supplement 1. Aggregation propensity of co-complex members of aneuploid proteins in the case of deletions.

Protein abundance correlations between differentially abundant proteins on aneuploid chromosomes and their co-complex members on other chromosomes when co-complex proteins are grouped as aggregation-prone and non-aggregation-prone, in deletion cases. Wilcoxon test was used to test the difference between two groups.