Table 1.
Semi-quantitative expression of 29 proteins involved in endothelial function and inflammation analyzed in conditioned media of ctrl (n = 3) and lip (n = 3) SVF cells.
| Protein Name | ctrl (A.U. Mean ± SD) |
lip (A.U. Mean ± SD) |
p-Value | ||||
|---|---|---|---|---|---|---|---|
| IL-8 | 1004 | ± | 639 | 191 | ± | 100 | 0.049 |
| TIMP-1 | 404 | ± | 204 | 856 | ± | 455 | 0.176 |
| TIMP-2 | 287 | ± | 164 | 525 | ± | 309 | 0.287 |
| IL-12p40 | 415 | ± | 364 | 631 | ± | 243 | 0.386 |
| IL-11 | 336 | ± | 135 | 414 | ± | 95 | 0.408 |
| IL-6 | 621 | ± | 99 | 4149 | ± | 6814 | 0.422 |
| MCP-1 | 2717 | ± | 348 | 2998 | ± | 702 | 0.558 |
| bFGF | 249 | ± | 190 | 319 | ± | 168 | 0.627 |
| IL-13 | 105 | ± | 154 | 63 | ± | 75 | 0.648 |
| VEGF-D | 169 | ± | 127 | 217 | ± | 148 | 0.671 |
| IGF-1 | 350 | ± | 310 | 277 | ± | 132 | 0.684 |
| MMP-1 | 5711 | ± | 3794 | 7004 | ± | 4061 | 0.686 |
| uPAR | 285 | ± | 273 | 357 | ± | 198 | 0.700 |
| IGF-2 | 185 | ± | 192 | 231 | ± | 170 | 0.750 |
| TLR3 | 47 | ± | 60 | 64 | ± | 73 | 0.755 |
| HGF | 220 | ± | 214 | 167 | ± | 216 | 0.757 |
| PECAM-1 | 165 | ± | 170 | 134 | ± | 123 | 0.791 |
| MMP-9 | 203 | ± | 178 | 235 | ± | 146 | 0.803 |
| TGF-beta | 264 | ± | 321 | 322 | ± | 309 | 0.821 |
| VEGF-A | 197 | ± | 137 | 227 | ± | 181 | 0.825 |
| IFN-gamma | 276 | ± | 231 | 306 | ± | 133 | 0.834 |
| IL-10 | 127 | ± | 130 | 143 | ± | 106 | 0.860 |
| TLR4 | 90 | ± | 89 | 81 | ± | 61 | 0.880 |
| TPO | 116 | ± | 129 | 104 | ± | 105 | 0.899 |
| IL-4 | 220 | ± | 206 | 238 | ± | 168 | 0.902 |
| IL-1beta | 197 | ± | 163 | 206 | ± | 136 | 0.936 |
| Leptin | 68 | ± | 83 | 66 | ± | 72 | 0.972 |
| EGF | 8696 | ± | 3611 | 8709 | ± | 2820 | 0.996 |
| TNF-alpha | 186 | ± | 169 | 186 | ± | 156 | 0.999 |
Statistical analysis: Student’s two-tailed t-test. Abbreviations: Ctrl: control; lip: lipedema; A.U.: arbitrary units; IL: interleukin; IFN: interferon; MCP: monocyte-chemoattractant protein; TIMP: tissue inhibitor of metalloproteinases; MMP: matrix metallopeptidase; TNF: tumor necrosis factor; uPAR: plasminogen activator surface receptor; TPO: thyroid peroxidase; PECAM: platelet and endothelial cell adhesion molecule; HGF: hepatocyte growth factor; EGF: epidermal growth factor; IGF: insulin-like growth factor; TGF: transforming growth factor; bFGF: basic fibroblast growth factor; VEGF: vascular endothelial growth factor; TLR: toll-like receptor.