Figure 3.

Bacterial microbiota in correlation to clinical outcomes in COVID-19 patients. (A) Bacterial species biomarkers associated with respiratory SOFA (Sequential Organ Failure Assessment) score or PaO2/FiO2 level. (B) Bacterial species biomarkers associated with oxygen saturation (SpO2) level or oxygen support. The biomarkers were identified by linear discriminative analysis (LDA) effect size (LEfSe) analysis. LDA scores (log 10) for the enriched species in a given group are represented with colors as shown. The LEfSe alpha value was set at 0.05, the threshold used to consider a discriminative feature for the LDA score was set at >2. (C) Correlation between bacterial species and markers of respiratory and inflammatory status. Spearman’s correlation rho values are represented by color gradient as indicated (red is for positive, green is for negative correlation). Only correlations with p < 0.05 are shown on the plots.