Table 1.
Multivariable logistic regression analysis parameters predictive of severe fever with thrombocytopenia syndrome and the diagnostic performance of the clinical scoring system in differentiating severe fever with thrombocytopenia syndrome.
| Model | Multivariable Logistic Regression Analysis |
Odds Ratio (95% CI) |
p- Value | AUC (95% CI) |
p- Value | Sensitivity (95% CI) |
Specificity (95% CI) |
|---|---|---|---|---|---|---|---|
| A | Altered mental status | 5.681 (1.369–23.571) | 0.017 | 0.974 (0.949–0.989) | <0.001 | 91.9 (86.3–95.7) | 96.3 (91.6–98.8) |
| Leukopenia (WBC count <4000/μL) | 75.879 (14.418–399.323) | <0.001 | |||||
| Prolonged aPTT (>40 s) | 80.133 (14.369–446.877) | <0.001 | |||||
| Normal CRP level (≤1.0 mg/dL) | 166.855 (23.482–1185.613) | <0.001 | |||||
| B | Altered mental status | 15.385 (2.216–106.828) | 0.006 | 0.983 (0.960–0.995) | <0.001 | 97.3 (93.2–99.3) | 95.6 (90.6–98.4) |
| Leukopenia (WBC count < 4000/μL) | 92.573 (14.971–572.430) | <0.001 | |||||
| Prolonged aPTT (>40 s) | 65.010 (10.510–402.105) | <0.001 | |||||
| Normal CRP level (≤3.0 mg/dL) | 184.937 (35.731–957.207) | <0.001 | |||||
| C | Leukopenia (WBC count < 4000/μL) | 145.404 (12.686–1666.604) | <0.001 | 0.992 (0.971–0.999) | <0.001 | 97.3 (92.4–99.4) | 97.8 (93.6–99.5) |
| Prolonged aPTT (>40 s) | 250.124 (18.403–3399.536) | <0.001 | |||||
| Normal CRP level (≤3.0 mg/dL) | 172.021 (26.289–1125.629) | <0.001 | |||||
| Elevated CK level (>1000 IU/L) | 192.616 (8.307–4466.445) | 0.001 | |||||
| D | Leukopenia (WBC count <4000/μL) | 14.312 (6.228–32.887) | <0.001 | 0.945 (0.914–0.968) | <0.001 | 83.7 (77.2–89.0) | 95.0 (90.0–98.0) |
| Thrombocytopenia (PLT < 80 k) | 7.231 (3.091–16.912) | <0.001 | |||||
| Normal CRP level (<1.0 mg/dL) | 73.889 (15.752–346.587) | <0.001 |
Abbreviations: CI, confidence interval; WBC, white blood cell; aPTT, activated partial thromboplastin time; CRP, C-reactive protein; CK, creatine kinase; PLT, platelet count test.