Table 1.

Equilibrium solubility values of apremilast (APR) in different oils, surfactants, cosurfactants, and water at 25 °C (mean ± SD, n = 3).

Components	Solubility ± SD (mg/mL)
Water	0.01 ± 0.00
Ethanol	0.66 ± 0.01
IPA	2.07 ± 0.10
EG	7.21 ± 0.52
PG	7.96 ± 0.64
Triacetin	11.42 ± 0.95
PEG-400	12.36 ± 0.28
Capryol-90	18.15 ± 1.03
Capryol-PGMC	21.41 ± 1.32
Lauroglycol-90	28.21 ± 1.45
Cremophor-EL	33.81 ± 2.04
Lauraglycol-FCC	36.54 ± 2.78
Labrasol	37.54 ± 2.14
Triton-X100	41.24 ± 3.12
Tween-80	48.54 ± 3.76
Transcutol-HP	55.01 ± 3.19