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Schematic representation of pTOP vaccine. The pTOP is a plasmid DNA encoding a VSV-G sequence modified by the insertion of tumor epitope sequences in permissive sites. After administration of pTOP, cells will produce VSV-G vesicles incorporating CD4 and/or CD8 epitopes. These immunogenic vesicles will activate both the innate immunity and the adaptive immunity by presentation of the epitopes through the MHC class I or II molecules to the CD8 or CD4 T cells. (TCR = T cell receptor).
