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Impairment of peripheral blood CD8+ T cell subsets maturation in patients with COVID-19. Abnormalities of cytotoxic T cell maturation were linked with the increase in effector Th cell subsets. The relative number of activated (CD38+ and HLA-DR+) and ‘enhanced’ (PD-1+ and TIM-3+) cells were increased during the acute phase of SARS-CoV-2 infection.
