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. 2022 May 31;10:82. doi: 10.1186/s40168-022-01271-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — 3-HPA and 4-HPA are identified to be involved in the protection of running in MI. OPLS-DA Model Discrimination based on metabolic profiles in fecal samples. A The relative abundance of each metabolite classes in different groups (n = 10:10:10:10). B The abundance of phenols in different groups. C Volcano plot of univariate statistics across Sham + control group and MI + control group. D Volcano plot of univariate statistics across Sham + control group and Sham + Run group. E Pathway analysis bubble plot by mmu set in MI + Control vs MI + Run. F Network for statistically significant changed pathways in MI + control vs. MI + Run. G The relationship between metabolites and the top 50 genera in four groups was estimated by Spearman’s correlation analysis. Those with low correlated (|r|< 0.1) were not shown. Genera and cardiac function index were distinguished as positive (red) and negative (blue) correlation. *p < 0.05; **p < 0.01; ***p < 0.001