Table 6.

Test performance among women screened at age 60-64 years in the English HPV screening pilot’s first round; detection of CIN3+ and cervical cancer after a positive screening test, by screening test. Includes first rounds in the pilot in 2013-16, with follow-up for investigation of abnormalities by the end of 2019 (information on cervical cancer available until the end of 2018)

After a positive screen	HPV testing	Cytology	HPV testing v cytology (ORadj (95% CI)) *
No of women screened	24 166	54 908
No of CIN3+ detected (No of CIN3+ detected per 1000 women screened)	62 (2.57)	83 (1.51)	1.69 (1.21 to 2.37)
No of cervical cancers detected (No of cervical cancers detected per 1000 women screened)	9 (0.37)	23 (0.42)	0.89 (0.41 to 1.92) †

CI=confidence interval; CIN3+=cervical intraepithelial neoplasia grade 3 or higher; HPV=high risk human papillomavirus; OR_adj=adjusted odds ratio.

^*Odds ratios (for the detection of CIN3+ or screen detected cervical cancer after a positive screen) were adjusted for age in years, decile of the Index of Multiple Deprivation, and laboratory site. Unadjusted estimates were similar to adjusted estimates and are reported in supplementary table S4.

^†Unadjusted estimates owing to a smaller number of cases.