TABLE 7.
Summary of ureter histopathologic changes
| Baboon | Hemorrhage | Edema | Necrosis | i | v | Thrombi | ci | Thickness (mm)* |
|---|---|---|---|---|---|---|---|---|
| Group 1: Kidney is from a CMAH expressing pig | ||||||||
| B9315 | 0.27 | 1.05 | 0.05 | 0.1 | 0 | 0 | 1.2 | 1.06 |
| B17315 | 0 | 1.1 | 0.7 | 0.35 | 0.1 | 0 | 1.8 | 1.84 |
| B17615 | 0.35 | 1.35 | 0 | 0.6 | 0.3 | .13 | 1.3 | 8.97 |
| B10815 | 0 | 1.0 | 0 | 0.5 | 0.35 | 0.3 | 1.25 | 5.67 |
| B5916 | 0.1 | 1.1 | 0 | 0.3 | 0.1 | 0.48 | 1.5 | 8.68 |
| Median | 0.1 | 1.1 | 0 | 0.35 | 0.1 | 0.13 | 1.3 | 4.64 |
| Group 2: Kidney is from a CMAHKO pig | ||||||||
| B8216 | 1.5 | 2.0 | 1 | 2.0 | 0 | 0.3 | 0 | 2.26 |
| B1417 | 0.18 | 0.36 | 1.3 | 1.3 | 0.18 | 0 | 1.8 | 2.78 |
| B3917 | 3.0 | 0 | 0.73 | 0.6 | 0.3 | 0.6 | 0 | 1.83 |
| B15816 | 0.05 | 1.5 | 0.4 | 0.3 | 0.3 | 0 | 2.0 | 4.71 |
| B517 | 0 | 1.1 | 0.13 | 0.43 | 0.18 | 0.13 | 1.4 | 2.95 |
| Median | 0.18 | 1.1 | 0.4 | 0.6 | 0.18 | 1.0 | 2.0 | 2.91 |
| p value | 0.54 | >0.99 | 0.0476 | 0.21 | 0.99 | 0.56 | 0.33 | 0.24 |
Hemorrhage, edema, necrosis, inflammation (i), vasculitis (v), and fibrosis (ci) were scored as described in Table 3.
*
Ureter thickness was assessed on low magnification (2x) by measuring the distance (μM) from mucosal apical surface to serosal apical surface. Mean thickness is reported for each group, and an unparied Student’s t test was used to evaluate for statistical for significance (p < 0.05). For all other semi-quantitative parameters, data are reported as median values and non-parametric statistical significance (Mann–Whitney U test) analyses are reported.