Extended Data Fig. 11 |. PPARγ in T cells is dispensable for the insulin-sensitizing action of TZDs.

a–d, Glucose tolerance tests (GTTs) of Control (a, b) or PPARγ TKO (c, d) mice that have been treated with or without Rosi. Glucose and insulin traces (a, c) and corresponding area under the curves (AUCs) (b, d) are presented. Control, Cd4^Cre; PPARγ TKO, Cd4^Cre Pparg^fl/fl; For (a–d) n = 10 for all Control mice with exception in (a, b) where n = 9 for the glucose measurements for mice treated with Rosi; n = 8 for PPARγ TKO mice with exception in (c, d) where n = 7 for the PPARγ TKO Rosi-treated mice that were sampled for the serum glucose measurements and n = 5 for the PPARγ TKO Rosi-treated mice that were sampled for the serum insulin measurements. Gluc., Glucose; Ins., Insulin; Rosi, Rosiglitazone. This experiment was conducted once with a weight- and age-matched cohort. Data are mean ± s.e.m. *P < 0.05, **P < 0.01.