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. 2022 Jun 4;15(8):7267–7285. doi: 10.1007/s12274-022-4385-4

Emerging prospects of protein/peptide-based nanoassemblies for drug delivery and vaccine development

Taiyu Liu 1, Lu Li 1, Cheng Cheng 1, Bingfang He 1, Tianyue Jiang 1,✉
PMCID: PMC9166156  PMID: 35692441

Abstract

Proteins have been widely used in the biomedical field because of their well-defined architecture, accurate molecular weight, excellent biocompatibility and biodegradability, and easy-to-functionalization. Inspired by the wisdom of nature, increasing proteins/peptides that possess self-assembling capabilities have been explored and designed to generate nanoassemblies with unique structure and function, including spatially organized conformation, passive and active targeting, stimuli-responsiveness, and high stability. These characteristics make protein/peptide-based nanoassembly an ideal platform for drug delivery and vaccine development. In this review, we focus on recent advances in subsistent protein/peptide-based nanoassemblies, including protein nanocages, virus-like particles, self-assemblable natural proteins, and self-assemblable artificial peptides. The origin and characteristics of various protein/peptide-based assemblies and their applications in drug delivery and vaccine development are summarized. In the end, the prospects and challenges are discussed for the further development of protein/peptide-based nanoassemblies.

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Keywords: drug delivery, vaccine, protein/peptide, self-assembly, targeting, controlled release

Acknowledgements

This work was supported by the National Key Research and Development Program of China (No. 2019YFA0905200), the National Natural Science Foundation of China (No. 82072045), and the Natural Science Foundation of Jiangsu Province of China for Excellent Young Scholars (No. BK20190084).

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