Table 3.
QFe/age in hemochromatosis probands with HFE p.C282Y homozygosity a
| Highest quartile, QFe/age, mg/y (n = 26) | Lowest three quartiles, QFe/age, mg/y (n = 78) | Value of p | ||
| Men (n = 104) | Median QFe/age, mg/y (range) | 1913 (1226, 7143)b | 486 (0, 1217)b | < 0.0001 |
| HLA-Aa03 positivity c, % (n) | 76.9 (20) | 85.9 (67) | 0.3583 | |
| HLA-Aa03 allele frequency d (n) | 0.4615 (24/52) | 0.5385 (84/156) | 0.8535 | |
| Highest quartile, QFe/age, mg/y (n = 19) | Lowest three quartiles, QFe/age, mg/y (n = 57) | Value of p | ||
| Women (n = 76) | Median QFe/age, mg/y (range) | 1667 (1212, 6452) | 444 (0, 1133) | < 0.0001 |
| HLA-Aa03 positivity c, % (n) | 68.4 (13) | 71.9 (41) | 0.7765 | |
| HLA-Aa03 allele frequency d (n) | 0.4737 (18/38) | 0.4561 (52/114) | 0.3424 | |
a Abbreviations: HLA human leukocyte antigen, QFe/age is defined as the quotient of quantity of iron removed to achieve iron depletion by age at diagnosis (mg/y)
b These values did not differ significantly from corresponding values in women
c Positivity is defined as either A*03 homozygosity or heterozygosity
d Allele frequency is defined as the quotient of total A*03 alleles by total A alleles