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. 2022 May 16;12(9):4200–4220. doi: 10.7150/thno.70896

Figure 7.

Figure 7

Histochemistry analysis of aortic root sections from ApoE-/- mice after different treatments. (A) Representative photographs of aortic root sections from ApoE-/- mice after treatment with different formulations (saline, RAP, RAP@NPs, RAP@T/R NPs at a dose of 0.5 mg/kg RAP twice a week) stained with H&E, Masson's trichrome, antibody to CD68, antibody to MMP-9, CTSK, and antibody to α-SMA (positive arear: dotted frame, Scale bar: 200 µm, n = 5). (B-G) Quantitative analysis of plaque area (B), collagen area relative to plaque area (C), macrophage area relative to plaque area (D), MMP-9 area relative to plaque area (E), CTSK area relative to plaque area (F), and VSMCs area relative to plaque area (G) (n = 5).