Table 1. Minimum inhibitory concentration (MIC) (µg/ml) of ATCC 19977 +/-penicillin-binding protein and hypothetical lipoprotein (PBP-lipo) knockdown.
| Antibiotic | -ATc | +ATc | Fold difference in MIC(-ATc/+ATc) |
|---|---|---|---|
| Cell wall | |||
| Ampicillin | >256 | 2 | >128× |
| Amoxicillin | >256 | 2 | >128× |
| Faropenem | 8 | 1 | 8× |
| Cefoxitin | 8 | 2 | 4× |
| Vancomycin | 8 | 2 | 4× |
| Imipenem | >64 | >64 | - |
| Ticarcillin | >64 | >64 | - |
| Ceftazidime | >64 | >64 | - |
| Cephalexin | >64 | >64 | - |
| Ceftazidime | >64 | >64 | - |
| D-Cycloserine | >64 | >64 | - |
| Ethambutol | >64 | >64 | - |
| Isoniazid | >512 | >512 | - |
| Ribosome | |||
| Clarithromycin | 16 | 0.125 | 128× |
| Erythromycin | 32 | 0.5 | 64× |
| Amikacin | 16 | 4 | 4× |
| Clindamycin | >64 | 64 | - |
| RNA polymerase | |||
| Rifampicin | 32 | 2 | 16× |
| DNA gyrase | |||
| Ofloxacin | 8 | 2 | 4× |
| Other | |||
| Pyrazinamide | >64 | >64 | - |
| Pretomanid | >64 | >64 | - |