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. 2022 Jun 1;606(7913):329–334. doi: 10.1038/s41586-022-04757-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Distribution of heterozygous variants maintained in the S2 inbreeding pedigree along the four chromosomes. The y axis shows variant counts per 10 Mb. Green, pink and blue boxes represent inversions 1, 2 and 3, respectively. b, Number of meiotic recombination events on chromosomes 1 and 3 in oocytes (red) and sperm cells (cyan). Dots represent individual gametes, summarized with violin plots. c, Chromosome 1 in late prophase I in oocytes from J/V worms (left and right panels) shows fewer crossovers than in oocytes from J/J worms (middle panel). This experiment was repeated more than 10 times independently with similar results. The right panel shows FISH⁴² results with probes for the telomeric repeat TTAGGG (magenta) and a repeat located near the centromere (yellow). This experiment was repeated more than three times independently with similar results. d, Chromatin contact heat map for chromosome 1. Dashed-line rectangles indicate the locations of potential inversions. Arrows indicate chromatin contact signals with inversion regions from unassigned scaffolds.