Figure 2.

Ldlr^−/− mice with P407 injection had reduced atherosclerosis. Ldlr^−/− mice were fed the WD and simultaneously injected with P407 or the saline control and were sacrificed at 7 weeks of WD and P407 or saline injection. Atherosclerotic plaque size was quantified in (A) whole aortas and (B) aortic sinus areas after oil red O staining. Data are presented as (A) mean ± SEM or (B) median with 95% confidence interval. Unpaired Student’s t-test (A) or Mann–Whitney test (B) was used for statistical analysis. (C) Representative images of macrophages in aortic sinus atherosclerotic plaques after staining for Mac-3 (green), CD11c (red), and DAPI (blue).