Table 1.
Characteristics of Included studies.
| Study | Biomarker (s) | Number of subjects | Antipsychotic (s) | Trial Length (days) | Risk of Biasa |
|---|---|---|---|---|---|
| Albaugh 201110 | Leptin | 15 | Olanzapine | 3 | Low |
| Ballon 201811 | Adiponectin, cortisol, c-peptide, GH, glucagon, IL-6, leptin, TNFα | 24 | Iloperidone, Olanzapine | 28 | Low |
| Baptista 1997a12 | Cortisol, DHEA, E2, FSH, LH, prolactin, testosterone, T4, TSH | 14 | Sulpride | 30 | Some concerns |
| Baptista 1997b13 | Cortisol, DHEA, E2, FSH, LH, progesterone, prolactin, testosterone, T4, TSH | 34 | Sulpride | 28 | Some concerns |
| Cohrs 200414 | Cortisol, melatonin | 13 | Quetiapine | 2 | Some concerns |
| Cohrs 200615 | ACTH, cortisol, prolactin | 11 | Haloperidol, Olanzapine, Quetiapine | 1 | Some concerns |
| Daurignac 201516 | Leptin | 19 | Olanzapine | 14 | Some concerns |
| de Borja Gonçalves Guerra 200517 | ACTH, cortisol, GH, prolactin | 15 | Quetiapine | 1 | Some concerns |
| Fountaine 201018 | Adiponectin, cortisol, CRP, ghrelin, IL-6, leptin, prolactin, TNFα | 21 | Olanzapine | 15 | Some concerns |
| Hahn 201319 | Adiponectin, cortisol, c-peptide, CRP, FFA, IL-6, leptin, prolactin, TNFα | 15 | Olanzapine | 1 | Some concerns |
| Handley 201620 | Cortisol, IL-6 | 17 | Aripiprazole, Haloperidol | 1 | Some concerns |
| Lee 199521 | Prolactin | 10 | Clozapine, Haloperidol | 1 | Some concerns |
| Liem-Moolenaar 201022 | Cortisol, FSH, LH, prolactin | 22 | Haloperidol | 1 | Some concerns |
| Mallikaarjun 200423 | Prolactin | 38 | Aripiprazole | 14 | Some concerns |
| Nahmias 202024 | FFA, prolactin | 8 | Olanzapine | 1 | Some concerns |
| Pretorius 200125 | prolactin | 12 | Clozapine, Haloperidol | 1 | Low |
| Rickels 201826 | GIP, PP | 15 | Olanzapine | 9 | Some concerns |
| Roerig 200827 | Ghrelin | 28 | Olanzapine, Risperidone | 14 | Low |
| Samuels 200628 | Prolactin, TSH | 16 | Amisulpride | 1 | Some concerns |
| Sowell 200229 | C-peptide | 48 | Olanzapine, Risperidone | 15–17 | Some concerns |
| Sowell 200330 | FFA | 55 | Olanzapine, Risperidone | 21 | Some concerns |
| Teff 201331 | C-peptide, ghrelin, glucagon, GLP-1, leptin | 30 | Aripiprazole, Olanzapine | 9 | Some concerns |
| Veselinović 201132 | Prolactin | 54 | Haloperidol | 7 | Some concerns |
| Veselinović 201833 | Prolactin | 54 | Aripiprazole, Haloperidol | 7 | Some concerns |
| Vidarsdottir 200934 | Cortisol, prolactin | 12 | Olanzapine | 8 | Low |
| Vidarsdottir 2010a35 | CCK, ghrelin, GLP-1, glucagon, PP, PYY | 10 | Olanzapine | 8 | Low |
| Vidarsdottir 2010b36 | Adiponectin, FFA, leptin | 12 | Olanzapine | 8 | Low |
| Wetzel 199437 | Cortisol, GH, LH, prolactin, TSH | 8 | Amisulpride | 1 | Some concerns |
Abbreviations: ACTH=Adrenocorticotropic hormone; CCK= Cholecystokinin; CRP=c-reactive protein; DHEA=Dehydroepiandrosterone; E2=estrogen; FFA=free fatty acid; FSH=follicle stimulating hormone; GIP=Gastric inhibitory polypeptide; GH=growth hormone; GLP-1=Glucagon Like Peptide-1; LH=luteinizing hormone; IL-6=interleukin-6; PAI=Plasminogen activator inhibitor; PP=pancreatic polypeptide; PYY=peptide YY; T4=thyroxine; TNFα=tumor necrosis factor alpha; TSH=thyroid stimulating hormone
a
see supplementary data for full evaluations.