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. 2022 Jun 17;17(6):e0269971. doi: 10.1371/journal.pone.0269971

Confidence interval estimation of the common mean of several gamma populations

Li Yan 1,*
Editor: Miguel A Fernández2
PMCID: PMC9205481  PMID: 35714130

Abstract

Gamma distributions are widely used in applied fields due to its flexibility of accommodating right-skewed data. Although inference methods for a single gamma mean have been well studied, research on the common mean of several gamma populations are sparse. This paper addresses the problem of confidence interval estimation of the common mean of several gamma populations using the concept of generalized inference and the method of variance estimates recovery (MOVER). Simulation studies demonstrate that several proposed approaches can provide confidence intervals with satisfying coverage probabilities even at small sample sizes. The proposed methods are illustrated using two examples.

Introduction

Due to its flexibility of accommodating right-skewed data, the standard two-parameter Gamma distribution has been widely used in many applied fields such as meteorology, reliability, medical science, engineering and quality control [14]. Under many circumstances, the research interest lies in making inference about the mean. There exit abundant research regarding making inference about gamma mean(s). For example, Fraser et al. [5] investigated inference methods for gamma mean based on asymptotic approximation, and Krishnamoorthy and León-Novelo [6] investigated small sample inference for gamma parameters for one-sample and two-sample problems. Recently, several fiducial methods [79] constructed approximate generalized pivotal quantities for a single gamma mean in different ways. Wang et al. [10] extended a fiducial approach [7] for a single gamma mean to construct a fiducial confidence interval for the difference between two independent gamma means.

There also exist some research on testing equality of several gamma means. For example, Chang et al. [11] proposed a parametric bootstrap method for comparing several gamma means, and Krishnamoorthy et al. [12] presented likelihood ratio test for comparing several gamma distributions. When testing equality of several gamma means concludes the null hypothesis (i.e. all the means are equal) can not be rejected, naturally, making inference about the common mean is of interest. Despite the fact that inference procedures about the common gamma means are of practical and theoretical importance, there has not yet been a well-developed approach for this purpose at small sample sizes except some traditional large sample methods. Therefore, the goal of this paper is to present accurate small sample inference methods for confidence interval estimation for the common gamma mean derived from several independent samples.

The rest of this paper is organized as follows. We will first present preliminaries including notations and existing methods for confidence interval estimation of single gamma mean. Then we will propose several methods for constructing confidence intervals for common gamma mean. Simulation results are presented to evaluate the performance of the proposed methods and examples are analyzed using the proposed methods. Finally, summary and discussion are given.

Preliminaries

The setting

Consider K independent gamma populations. Let Yi1,Yi2,,Yini be a random sample from the ith gamma population as Yijgamma(αi, βi) where αi is shape parameter and βi is rate parameter; i.e. the corresponding probability density function for Yij is

f(yij;αi,βi)=yijαi1eβiyijβiαiΓ(αi)

for yij > 0, αi, βi > 0. Let μi denote the population mean for ith sample. Then μi = αi/βi for i = 1, 2, …, K. We assume that μ1 = μ2 = … = μK and let μ denote the common mean. The goal of this paper is to present procedures for confidence interval estimation of μ at small to medium sample sizes.

Let α^i and β^i stand for the maximum likelihood estimates for αi and βi, respectively. The maximum likelihood estimate of μi is μ^i=Y¯i=α^i/β^i where the large sample variance for μ^i is [5]

var(μ^i)=μi2niαi, (1)

and its estimate is

var^(μ^i)=μ^i2niα^i. (2)

The common gamma mean can be estimated as a pooled estimate of sample means defined as

μ^=i=1Kμ^ivar^(μ^i)/i=1K1var^(μ^i) (3)

Using standard large sample theory, we have

μ^μvar(μ^)N(0,1)

asymptotically. Hence, a simple large sample solution for confidence interval estimation for common μ is

(μ^z1α/21/i=1K1/var^(μ^i),μ^+z1α/21/i=1K1/var^(μ^i)). (4)

Of course, we also can obtain a large sample confidence interval using standard maximum likelihood theory. However, these large sample solutions do not have good performance at small sample sizes. Hence in this paper, we will present some procedures with satisfactory performance.

Existing methods for confidence interval estimation for single gamma mean

In the following, we will review several existing methods for confidence interval estimation for single gamma mean. These methods are known to have reasonable performance at small to medium sample sizes, and will be used in the following to present our new procedures for confidence interval estimation for common gamma mean.

Let Y1, Y2, …, Yn be a random sample from a gamma population gamma(α, β). The population mean μ = α/β. Let Y¯ and Y˜ denote the arithmetic mean and geometric mean, respectively. The maximum likelihood estimate of μ is μ^=Y¯=α^/β^ where α^ and β^ are the maximum likelihood estimates for α and β, respectively.

Methods based on generalized inference

The generalized variables and generalized pivots were introduced by Tsui and Weerahandi [13] and Weerahandi [14]. More details can be found in the book by Weerahandi [15]. The concepts of generalized pivotal quantity and generalized confidence interval have been successfully applied to a variety of practical problems where standard exact solutions do not exist and it has been shown that generalized inference method generally have good performance, even at small sample sizes; see e.g. [1621]. Recently, Hannig et al. [22] demonstrated generalized confidence intervals coincide with fiducial confidence intervals. In the following, we review three existing methods for constructing generalized pivotal quantity for single gamma mean.

Krishnamoorthy and Wang’s method: [7, 23] This method is based on the fact that Xj=Yj13 (j = 1, 2, …, n) follows N(μ, σ2) approximately for gamma distribution. Let x¯ and si2 be the observed sample mean and sample variance based on the transformed data Xis. The generalized pivotal quantities for μ and σ2 can be obtained as [24]:

Rμ=x¯ZU(n1)s2n,Rσ2=(n1)s2U(n1)s2χn12

where ZN(0, 1), Uχn12, and Z and U are independent. Furthermore, the generalized pivotal quantities for for α and β can be written as:

Rα=19{(1+0.5Rμ2Rσ2)+[(1+0.5Rμ2Rσ2)21]12},Rβ=127(Rα)12(Rσ2)32. (5)

Chen and Ye’s method: [8, 25] Note that V1=2nαlog(Y¯/Y˜)cχν2 approximately, where ν = 2E2(V1)/var(V1), c = E(V1)/ν, E(V1) = 2(ψ() − ψ(α) − log(n)) and var(V1) = 4n2 α2(ψ′(α)/nψ′(α)) with ψ and ψ′ being the digamma and trigamma functions respectively. Then c^ and v^ can be obtained by substituting α with its point estimate α^. An approximate generalized pivotal quantity (GPQ) for α is:

Rα=V12nlog(y¯/y˜)

where V1c^χv^2, y¯ and y˜ are observed values of Y¯ and Y˜. Furthermore, as 2nβY¯χ2nα2, a GPQ for β can be constructed as:

Rβ=V22ny¯, (6)

where V2χ2nRα2.

Wang and Wu’s method [9]: This method is based on Cornish-Fisher approximation. Let T=log(Y˜/Y¯) and F(.) be the c.d.f. of T. Note that U = F(T)∼U(0, 1). Using the Cornish-Fisher expansion, the Uth percentile of T can be approximated by g1(α) + [g2(α)]1/2 Q(α, U), where gi(α) is the ith cumulant of T and Q(α, U) is a function of gi(α)’s. Detailed formula can be found in [9]. Let t denote the observed value of T. Solving t = g1(α) + [g2(α)]1/2Q(α, U) for α, we obtain the approximate Rα. The GPQ for β can be obtained similarly as in (6):

Rβ=V32ny¯, (7)

where V3χ2nRα2. This method improves Chen and Ye’s method and can work well even when the shape parameter α is small.

The three aforementioned methods for generating Rα and Rβ lead to three generalized pivots of a single gamma mean:

Rμ=Rα/Rβ. (8)

Via simulation, we can obtain an array of Rμ’s and the estimated confidence interval for μ is (Rμ(α/2), Rμ(1 − α/2)) where Rμ(α) is the 100αth percentile of Rμ’s.

A parametric bootstrap method [6]

Krishnamoorthy and León-Novelo [6] presented a method based on parametric bootstrapping for confidence interval estimation using the following pivotal quantity:

Q=Y¯*Y¯Y¯*/nα^* (9)

where α^* and Y¯* are based on a bootstrap sample from Gamma(α^,β^) distribution. A two-sided 100(1 − p)% confidence interval (l, u) for μ is:

(Y¯Q1p/2Y¯nα^,Y¯Qp/2Y¯nα^), (10)

where Qp as the 100pth percentile of Q defined in (9).

The proposed methods for confidence interval estimation of common gamma mean

The methods based on generalized inference

For the ith (i = 1, 2, …, K) sample, we can obtain the generalized pivotal quantities Rμi using one of the three methods reviewed above (i.e. Krishnamoorthy and Wang’s method [7, 23] Chen and Ye’s method [8, 25], and Wang and Wu’s method [9]). Replacing μi and αi with Rμi and Rαi in (1), the generalized pivotal quantity for var(μ^i) can be written as

Rvar(μ^i)=Rμi2niRαi. (11)

The generalized pivotal quantity we propose for the common gamma mean μ is a weighted average of the generalized pivot Rμi’s based on K individual samples, i.e.

Rμ=i=1KRwiRμii=1KRwi (12)

where Rwi=1/Rvar(μ^i).

It is easy to see that Rμ satisfies the two conditions to be an approximate bona fide generalized pivotal quantity: 1) the distributions of Rμ is independent of any unknown parameters; and 2) the observed value of Rμ equals to the common gamma μ approximately. This way of constructing generalized pivots for common mean has been widely used in literature. For example, Krishnamoorthy and Lu [17] studied inferences on the common mean of several normal populations based on the generalized variable method; and Tian and Wu [26] studied common mean of several log-normal populations.

Computing algorithms

Consider a given data set Yij’s (i = 1, 2, …, K, j = 1, 2, …, ni) where the ith sample Yi1,Yi2,,Yini is from gamma(αi, βi). We assume μi = μ for all i = 1, 2, …, K. The generalize confidence intervals for the common mean μ can be computed by the following steps:

  • 1

    Using one of the three methods presented above, generate Rαi and Rβi, then calculate generalized pivot Rμi for μi following (12) for i = 1, 2, …, K.

  • 2

    Repeat steps 1, generate Rαi and Rβi and calculate Rμi. Using Rαi and Rμi, calculate Rvar(μ^i) following (11) for i = 1, 2, …, K.

  • 3

    Using Rμi obtained in step 1 and Rvar(μ^i) in step 2 for i = 1, 2, …, K, calculate the generalized pivot of the common mean Rμ from (12).

  • 4

    Repeat Steps 1-3 a total B (B = 2000) times and obtain an array of Rμ’s.

  • 5

    Rank this array of Rμ’s from small to large.

The 100αth percentile of Rμ’s, Rμ(α), is an estimate of the lower bound of the one-sided 100(1 − α)% confidence interval and (Rμ(α/2), Rθ(1 − α/2)) is a two-sided 100(1 − α)% confidence interval.

Remark 2.1: In computing algorithm, we used different sets of random variables for Rμi and Rvar(μ^i). Our simulation shows that the generalized pivotal quantity based on the same set of random variables for Rμi and Rwi produces confidence intervals which are too liberal. Similar conclusions have been stated in [17, 26].

We refer these three methods based on the generalized pivots of common gamma mean as GVK, GVC, GVW, corresponding to the methods used for confidence interval estimation of a single gamma mean, i.e. Krishnamoorthy and Wang’s method [7, 23] Chen and Ye’s method [8, 25], and Wang and Wu’s method [9].

The MOVER-type methods

The method of variance estimates recovery (MOVER) is a useful technique for obtaining a closed-form approximate confidence interval for a linear combination of parameters based on the confidence intervals of the individual parameters [27, 28]. In this section, using the methods for estimating confidence intervals for a single gamma mean reviewed above, the MOVER method is applied for confidence interval estimation of the common gamma mean.

Let li and ui be the lower and upper limits of an approximate two-sided 100(1 − p)% confidence interval (li, ui) for the gamma mean based only on ith sample. A MOVER 100(1 − p)% confidence interval (L, U) of the common gamma mean is given by [27, 28]:

L=i=1Kw^iμ^ii=1Kw^i2(μ^ili)2U=i=1Kw^iμ^i+i=1Kw^i2(μ^iui)2, (13)

where w^i=(1/var^(μ^i))/i=1K(1/var^(μ^i)), var^(μ^i) is defined in (2), and α^i and μ^i=Yi¯ are the maximum likelihood estimates for αi and μi, respectively.

For calculating confidence intervals (lk, uk) for the single gamma mean μi (i = 1, …, K), we will use the three generalized inference methods (i.e. Krishnamoorthy and Wang’s method [7, 23], Chen and Ye’s method [8, 25], and Wang and Wu’s method [9]) as well as the parametric bootstrap method by Krishnamoorthy and León-Novelo [6] reviewed above. Each method provides an approximate confidence interval (li, ui) for the ith single gamma mean μi (i = 1, 2, …K).

Substituting (lk, uk) in (13), we obtain confidence interval estimation of common mean μ. We refer these MOVER-type methods as MOVERK, MOVERC, MOVERW, MOVERboot corresponding to the methods used for single gamma mean, i.e. Krishnamoorthy and Wang’s method [7, 23] Chen and Ye’s method [8, 25], Wang and Wu’s method [9], and the parametric bootstrap method by Krishnamoorthy and León-Novelo’s method [6], respectively.

Simulation studies

In previous section, we presented several methods for confidence interval estimation of common gamma mean: three methods based on the generalized pivots (i.e. GVK, GVC, GVW); and four MOVER-type methods (i.e. MOVERK, MOVERC, MOVERW, MOVERboot).

Simulation studies are carried out to evaluate the performances of proposed methods in terms of coverage probabilities and average lengths of proposed confidence intervals. The number of samples K is set as 2 and 5, and a variety of sample sizes from small (5) to large (50) including balanced and unbalanced settings are used. The parameter settings are as follows: 1) common mean μ is set as 1 and 5; 2) shape parameter for each sample varies from 0.5 or 1 to 5 or 10, and the differences among K shape parameters varies from small to large. For each parameter setting, 2,000 random samples are generated. For the confidence interval based on generalized pivots (i.e. GVK, GVC, GVW), MOVERK, MOVERC, MOVERW), 2000 values of generalized pivots are obtained for each random sample. For the confidence interval based on parametric bootstrapping (MOVERboot), 2000 bootstrap samples are generated for each random sample. The performances of each method is assessed by coverage probability and average lengths of proposed confidence intervals. The simulation results are presented in Tables 1 and 2.

Table 1. Coverage probabilities (CP) and length of confidence interval (CI) of proposed 95% confidence intervals for the common gamma mean (2000 simulations) with two independent samples (K = 2).

(α1, α2) Sizes* GVK GVC GVW MOVERK MOVERC MOVERW MOVERboot
CP CI CP CI CP CI CP CI CP CI CP CI CP CI
μ = 1
(0.5,1) I 0.947 3.798 0.977 31.948 0.962 9.138 0.910 2.927 0.950 28.028 0.927 8.921 0.903 2.670
II 0.952 2.131 0.976 10.748 0.966 4.693 0.917 2.411 0.952 35.248 0.941 9.745 0.917 2.443
III 0.955 1.458 0.969 1.896 0.964 1.722 0.916 1.260 0.940 1.628 0.936 1.496 0.927 1.337
IV 0.947 0.827 0.961 0.933 0.959 0.909 0.921 0.756 0.941 0.847 0.936 0.828 0.935 0.813
V 0.941 0.465 0.954 0.505 0.951 0.499 0.922 0.446 0.942 0.482 0.939 0.479 0.943 0.477
(1,2) I 0.965 2.274 0.974 4.504 0.966 2.656 0.927 1.804 0.942 3.353 0.930 2.126 0.917 1.441
II 0.957 1.319 0.969 2.027 0.960 1.483 0.931 1.464 0.948 2.957 0.936 1.810 0.922 1.202
III 0.958 0.971 0.966 1.050 0.960 0.992 0.926 0.860 0.933 0.922 0.931 0.879 0.924 0.839
IV 0.954 0.584 0.960 0.605 0.959 0.593 0.934 0.545 0.945 0.562 0.941 0.554 0.941 0.549
V 0.945 0.333 0.948 0.341 0.948 0.338 0.933 0.323 0.940 0.330 0.939 0.329 0.938 0.328
(1,10) I 0.959 1.035 0.964 1.532 0.960 1.108 0.933 0.825 0.946 1.326 0.932 0.927 0.911 0.725
II 0.967 0.579 0.971 0.798 0.969 0.629 0.948 0.643 0.954 1.187 0.946 0.771 0.934 0.551
III 0.957 0.478 0.962 0.494 0.961 0.481 0.941 0.434 0.945 0.445 0.941 0.436 0.940 0.427
IV 0.956 0.293 0.959 0.296 0.959 0.294 0.947 0.281 0.946 0.283 0.947 0.282 0.947 0.281
V 0.948 0.172 0.951 0.172 0.950 0.172 0.946 0.169 0.947 0.170 0.946 0.170 0.946 0.170
(2,10) I 0.960 0.891 0.963 1.023 0.953 0.862 0.931 0.727 0.933 0.812 0.927 0.709 0.917 0.647
II 0.954 0.526 0.957 0.576 0.953 0.525 0.933 0.562 0.940 0.653 0.934 0.560 0.921 0.491
III 0.964 0.446 0.964 0.453 0.961 0.444 0.943 0.408 0.939 0.411 0.943 0.405 0.935 0.400
IV 0.949 0.279 0.949 0.280 0.949 0.278 0.940 0.267 0.938 0.268 0.939 0.267 0.935 0.266
V 0.952 0.166 0.953 0.167 0.953 0.166 0.950 0.164 0.947 0.164 0.950 0.164 0.949 0.164
(5,10) I 0.964 0.732 0.969 0.762 0.961 0.690 0.932 0.612 0.931 0.626 0.925 0.586 0.920 0.561
II 0.960 0.478 0.963 0.489 0.960 0.467 0.944 0.497 0.946 0.510 0.936 0.480 0.935 0.456
III 0.956 0.390 0.956 0.392 0.957 0.387 0.934 0.358 0.936 0.358 0.934 0.355 0.936 0.352
IV 0.945 0.246 0.949 0.246 0.945 0.245 0.929 0.235 0.931 0.235 0.927 0.235 0.932 0.234
V 0.957 0.148 0.955 0.148 0.957 0.148 0.949 0.145 0.949 0.145 0.949 0.145 0.948 0.145
μ = 5
(0.5,1) I 0.956 18.934 0.977 152.736 0.965 46.391 0.923 14.473 0.953 163.612 0.936 46.134 0.907 13.224
II 0.958 10.803 0.977 49.275 0.969 22.734 0.924 12.269 0.952 184.086 0.936 46.080 0.924 12.116
III 0.956 7.174 0.974 9.363 0.966 8.501 0.917 6.177 0.941 8.038 0.931 7.393 0.927 6.588
IV 0.932 4.122 0.950 4.651 0.948 4.523 0.906 3.782 0.928 4.226 0.925 4.133 0.923 4.059
V 0.944 2.304 0.963 2.498 0.961 2.473 0.928 2.210 0.950 2.385 0.948 2.369 0.946 2.363
(1,2) I 0.957 11.242 0.975 21.977 0.961 13.098 0.921 8.943 0.942 16.556 0.925 10.592 0.912 7.177
II 0.961 6.637 0.976 10.351 0.966 7.517 0.938 7.429 0.954 15.540 0.944 9.356 0.924 6.099
III 0.965 4.859 0.975 5.258 0.967 4.971 0.934 4.306 0.943 4.618 0.936 4.407 0.930 4.198
IV 0.946 2.896 0.955 2.999 0.949 2.940 0.928 2.702 0.934 2.787 0.936 2.747 0.934 2.724
V 0.952 1.673 0.953 1.710 0.956 1.699 0.945 1.624 0.950 1.660 0.950 1.651 0.948 1.650
(1,10) I 0.963 5.098 0.969 7.328 0.967 5.373 0.935 4.086 0.947 6.156 0.933 4.451 0.919 3.588
II 0.969 2.857 0.976 3.868 0.969 3.095 0.955 3.201 0.963 5.952 0.952 3.868 0.939 2.746
III 0.958 2.398 0.960 2.482 0.956 2.411 0.938 2.170 0.940 2.229 0.940 2.183 0.933 2.138
IV 0.952 1.455 0.954 1.470 0.951 1.458 0.940 1.393 0.945 1.405 0.948 1.397 0.946 1.393
V 0.947 0.866 0.949 0.870 0.948 0.869 0.943 0.854 0.946 0.858 0.943 0.857 0.943 0.857
(2,10) I 0.960 4.540 0.965 5.190 0.956 4.367 0.926 3.701 0.931 4.105 0.923 3.602 0.917 3.287
II 0.954 2.639 0.957 2.890 0.953 2.635 0.935 2.822 0.937 3.278 0.934 2.815 0.925 2.471
III 0.961 2.215 0.963 2.246 0.959 2.199 0.945 2.025 0.948 2.043 0.946 2.012 0.943 1.986
IV 0.952 1.396 0.955 1.403 0.954 1.394 0.946 1.339 0.944 1.343 0.946 1.338 0.946 1.334
V 0.946 0.829 0.949 0.831 0.949 0.829 0.945 0.815 0.945 0.817 0.945 0.817 0.946 0.816
(5,10) I 0.951 3.645 0.960 3.794 0.953 3.439 0.911 3.054 0.919 3.123 0.909 2.923 0.910 2.798
II 0.962 2.383 0.966 2.432 0.961 2.319 0.942 2.473 0.944 2.536 0.934 2.385 0.936 2.267
III 0.963 1.962 0.963 1.971 0.960 1.944 0.943 1.801 0.943 1.804 0.942 1.787 0.942 1.772
IV 0.951 1.245 0.952 1.247 0.953 1.240 0.944 1.190 0.943 1.190 0.944 1.187 0.943 1.185
V 0.942 0.737 0.942 0.738 0.945 0.736 0.942 0.723 0.941 0.724 0.941 0.723 0.941 0.723

* I:(5,5), II:(5,10), III:(10,10), IV:(20,20), V: (50,50)

Table 2. Coverage probabilities (CP) and length of confidence interval (CI) of proposed 95% confidence intervals for the common gamma mean (2000 simulations) with two independent samples (K = 5).

(α1, α2) Sizes* GVK GVC GVW MOVERK MOVERC MOVERW MOVERboot
CP CI CP CI CP CI CP CI CP CI CP CI CP CI
μ = 1
(0.5,0.5,0.75,0.75,1) VI 0.962 2.618 0.995 89.847 0.979 8.961 0.879 1.590 0.959 19.057 0.926 5.422 0.830 1.471
VII 0.955 0.978 0.980 1.316 0.966 1.165 0.857 0.741 0.922 0.959 0.901 0.877 0.869 0.785
VIII 0.931 0.561 0.961 0.639 0.956 0.620 0.874 0.475 0.913 0.533 0.908 0.520 0.898 0.510
IX 0.959 0.687 0.984 2.241 0.975 1.184 0.927 1.196 0.966 15.958 0.949 4.277 0.913 1.213
X 0.923 0.309 0.955 0.338 0.951 0.335 0.901 0.287 0.930 0.311 0.927 0.309 0.927 0.308
(0.5,1,2,5,10) VI 0.970 0.903 0.987 3.417 0.976 1.300 0.901 0.609 0.944 2.858 0.922 1.146 0.863 0.551
VII 0.961 0.396 0.969 0.425 0.964 0.407 0.906 0.322 0.924 0.346 0.916 0.335 0.899 0.322
VIII 0.950 0.235 0.952 0.240 0.949 0.236 0.922 0.213 0.925 0.217 0.926 0.215 0.919 0.214
IX 0.966 0.210 0.978 0.427 0.970 0.276 0.946 0.420 0.969 4.520 0.958 1.434 0.919 0.412
X 0.956 0.135 0.960 0.137 0.957 0.136 0.947 0.130 0.950 0.132 0.948 0.132 0.947 0.131
(0.5,2,2,5,5) VI 0.966 0.977 0.983 3.781 0.972 1.435 0.895 0.670 0.936 5.867 0.911 1.594 0.864 0.609
VII 0.962 0.443 0.973 0.474 0.965 0.453 0.905 0.363 0.923 0.389 0.916 0.375 0.900 0.361
VIII 0.945 0.268 0.951 0.274 0.950 0.270 0.916 0.241 0.923 0.246 0.922 0.244 0.917 0.243
IX 0.957 0.276 0.976 0.602 0.965 0.368 0.944 0.504 0.966 5.257 0.954 1.571 0.922 0.495
X 0.955 0.153 0.959 0.155 0.958 0.154 0.943 0.147 0.943 0.149 0.942 0.148 0.944 0.148
(1,2,2,5,5) VI 0.971 0.916 0.983 1.551 0.972 0.954 0.904 0.629 0.924 0.887 0.901 0.654 0.864 0.537
VII 0.960 0.426 0.966 0.442 0.958 0.425 0.915 0.354 0.918 0.363 0.911 0.354 0.901 0.346
VIII 0.955 0.260 0.962 0.264 0.958 0.260 0.932 0.236 0.933 0.239 0.929 0.237 0.929 0.236
IX 0.964 0.252 0.972 0.299 0.965 0.263 0.945 0.444 0.954 0.796 0.949 0.522 0.920 0.377
X 0.945 0.151 0.948 0.152 0.945 0.151 0.939 0.145 0.941 0.146 0.938 0.146 0.940 0.146
(2,2,5,5,10) VI 0.968 0.654 0.979 0.820 0.970 0.633 0.898 0.465 0.908 0.513 0.892 0.452 0.864 0.413
VII 0.961 0.325 0.961 0.330 0.959 0.322 0.914 0.276 0.916 0.278 0.910 0.274 0.902 0.271
VIII 0.966 0.202 0.967 0.204 0.964 0.202 0.941 0.186 0.940 0.187 0.941 0.186 0.936 0.186
IX 0.961 0.180 0.967 0.188 0.959 0.180 0.936 0.302 0.948 0.345 0.932 0.300 0.915 0.267
X 0.964 0.118 0.958 0.119 0.961 0.118 0.954 0.114 0.953 0.115 0.953 0.114 0.953 0.114
μ = 5
(0.5,0.5,0.75,0.75,1) VI 0.968 12.835 0.994 396.747 0.982 43.412 0.882 7.805 0.964 126.406 0.924 32.435 0.835 7.311
VII 0.953 4.907 0.979 6.617 0.973 5.857 0.860 3.728 0.924 4.794 0.903 4.393 0.867 3.940
VIII 0.947 2.813 0.975 3.203 0.970 3.107 0.881 2.384 0.920 2.676 0.910 2.615 0.905 2.563
IX 0.957 3.430 0.985 10.460 0.976 5.677 0.918 5.834 0.962 63.516 0.947 20.451 0.906 5.913
X 0.928 1.552 0.961 1.695 0.960 1.679 0.899 1.437 0.930 1.557 0.931 1.546 0.928 1.542
(0.5,1,2,5,10) VI 0.972 4.566 0.987 19.559 0.979 7.006 0.897 3.095 0.946 18.131 0.917 6.738 0.858 2.842
VII 0.965 1.971 0.973 2.117 0.967 2.025 0.915 1.611 0.934 1.730 0.926 1.670 0.907 1.609
VIII 0.949 1.177 0.954 1.202 0.953 1.188 0.923 1.067 0.927 1.089 0.926 1.080 0.928 1.074
IX 0.957 1.047 0.976 2.291 0.968 1.384 0.939 2.091 0.959 24.026 0.949 7.508 0.919 2.071
X 0.950 0.675 0.953 0.681 0.950 0.679 0.939 0.650 0.945 0.657 0.944 0.656 0.944 0.656
(0.5,2,2,5,5) VI 0.966 4.907 0.984 16.560 0.974 6.850 0.894 3.356 0.936 19.666 0.912 6.848 0.860 3.047
VII 0.960 2.229 0.973 2.381 0.968 2.276 0.897 1.822 0.918 1.953 0.906 1.882 0.892 1.812
VIII 0.948 1.337 0.952 1.364 0.950 1.345 0.911 1.200 0.919 1.225 0.912 1.213 0.911 1.208
IX 0.959 1.391 0.973 3.026 0.968 1.882 0.934 2.512 0.959 25.382 0.947 8.083 0.913 2.437
X 0.952 0.766 0.952 0.775 0.949 0.772 0.939 0.735 0.943 0.744 0.942 0.742 0.943 0.741
(1,2,2,5,5) VI 0.966 4.606 0.979 7.967 0.966 4.825 0.901 3.162 0.923 4.510 0.897 3.319 0.858 2.697
VII 0.968 2.151 0.971 2.234 0.965 2.148 0.916 1.791 0.920 1.837 0.914 1.788 0.901 1.746
VIII 0.969 1.304 0.972 1.322 0.967 1.305 0.941 1.186 0.941 1.197 0.940 1.187 0.935 1.183
IX 0.956 1.267 0.972 1.499 0.961 1.321 0.933 2.208 0.948 4.063 0.936 2.631 0.913 1.882
X 0.958 0.751 0.955 0.757 0.952 0.753 0.946 0.722 0.947 0.727 0.945 0.725 0.946 0.725
(2,2,5,5,10) VI 0.965 3.276 0.970 4.063 0.960 3.143 0.901 2.312 0.912 2.527 0.891 2.243 0.870 2.063
VII 0.964 1.626 0.964 1.648 0.960 1.610 0.923 1.379 0.922 1.389 0.919 1.368 0.916 1.351
VIII 0.949 1.007 0.952 1.014 0.947 1.004 0.928 0.927 0.927 0.930 0.927 0.925 0.925 0.923
IX 0.958 0.896 0.964 0.937 0.956 0.899 0.939 1.514 0.947 1.740 0.938 1.506 0.922 1.337
X 0.951 0.591 0.953 0.593 0.950 0.591 0.941 0.572 0.942 0.573 0.942 0.572 0.941 0.573

* Sizes are VI:(5,5,5,5,5), VII:(10,10,10,10,10), VIII:(20,20,20,20,20), IX: (5,10,10,20,50), X: (50,50,50,50,50)

Table 1 presents simulated coverage probabilities (CP) and confidence interval lengths (CI) for K = 2. Overall speaking, three methods based on the generalized pivots (i.e. GVK, GVC, GVW) maintains satisfactory coverage probabilities for all settings except that they might be slightly conservative at small sizes and GVK was slightly liberal when (α1, α2) = (1, 2) at sample sizes (50, 50) and (α1, α2) = (0.5, 1) at sample sizes (20, 20). Among MOVER-type methods (i.e. MOVERK, MOVERC, MOVERW, MOVERboot), MOVERC performs the best while all of them are generally liberal when sample sizes are from (5, 5) to (20, 20). When sample sizes reach 50, all the proposed methods perform satisfactorily. The GVK method provides shortest confidence intervals among three generalized pivots based methods, followed by GVW. As sample sizes reach 20, all three methods (i.e. GVK, GVC, GVW) are generally comparable. MOVERK and MOVERboot provides shortest confidence intervals among MOVER-type methods. As sample sizes reach 20, all MOVER-type methods (i.e. MOVERK, MOVERC, MOVERW, MOVERboot) are comparable in terms of length. When sample sizes reach 50, all the proposed methods generate confidence intervals with comparable length.

Table 2 presents simulated coverage probabilities (CP) and confidence interval lengths (CI) for K = 5. The three generalized pivots based methods methods generally maintains satisfactory coverage probabilities for all settings except that they tend to be slightly conservative at small sizes and GVK is liberal at (α1, …, α5) = (0.5, 0.5, 0.75, 0.75, 1) with sizes (50, 50, 50, 50, 50). Among MOVER-type methods (i.e. MOVERK, MOVERC, MOVERW, MOVERboot), MOVERC performs the best while they are generally liberal when sample sizes are from (5, 5, 5, 5, 5) to (20, 20, 20, 20). When sample sizes reach 50, all methods perform satisfactorily. The GVK method provides shortest confidence intervals among three generalized pivots based methods, followed by GVW. As sample sizes reach 20, all three methods (i.e. GVK, GVC, GVW) are comparable. MOVERK provides shortest confidence intervals among three MOVER-type methods, followed by MOVERb oot. As sample sizes reach 20, all four methods (i.e. MOVERK, MOVERC, MOVERW, MOVERboot) are comparable. When sample sizes reach 50, all methods are generally comparable in terms of length.

In summary, generally we recommend GVK, GVC, GVW methods over MOVER-type methods due to the fact that they can generate confidence intervals with satisfactory coverage probabilities even at smaller sizes. The MOVER-type methods are not recommended unless sample sizes are greater than or equal to 50. The large sample approach in (4) can severely underestimate the coverage probabilities, hence its results are not presented.

Data examples

In this section, we illustrate the proposed methods using two examples. Both datasets was analyzed in [11] for testing equality of gamma means, and it was concluded that the null hypothesis (equality of gamma means) can not be rejected. Therefore, in this paper, we use these two datasets to illustrate our proposed methods for estimating confidence intervals of the common gamma mean.

Example 1. Wright [29] reported ground water yield from two types of wells in southwestern Virginia. Table 3 presents this dataset which includes ground water yield data from 12 wells from valley underlain by unfractured rocks, and 13 wells by fractured rocks. It has been argued that gamma distribution is appropriate to fit the data in each sample, and the test for equality of means [11] concluded that the means of water yields from two types of wells are the same. The estimated parameters are: α1 = 0.4342, β^1=2.2824, α2 = 1.1854, β^2=3.7707. The estimated 95% confidence intervals for the common gamma mean by all the proposed methods are presented in Table 4. Our simulation study demonstrate that MOVER-type methods could be liberal at sample sizes (10, 10). Give the sample sizes as 12 and 13 in this application, the confidence intervals by GVK, GVC, GVW methods are recommended, and among them the GVK method has the shortest length.

Table 3. Virginia ground water well yields data (in gal/min/ft) [29].

Without fractures with fractures
0.001, 0.003, 0.007, 0.020 0.020, 0.031, 0.085, 0.013
0.030, 0.040, 0.041, 0.077 0.160, 0.160, 0.180, 0.300
0.100, 0.454, 0.490, 1.020 0.400, 0.440, 0.510, 0.720, 0.950

Table 4. Estimated confidence interval for Virginia ground water well yields data (in gal/min/ft).

method lower upper LCI
GV K 0.140 0.491 0.351
GV C 0.159 0.576 0.417
GV W 0.153 0.574 0.421
MOVER K 0.169 0.459 0.289
MOVER C 0.178 0.548 0.370
MOVER W 0.175 0.530 0.355
MOVER boot 0.175 0.490 0.314

Example 2. Table 5 presents a dataset of chloride concentration in spring water samples from two types of rocks in Sierra Nevada, California and Nevada [30]. It has been argued that gamma distribution is appropriate to fit the data in each sample, and testing equality of means [11] concluded that the means of chloride concentration from two types of rocks are the same. The estimated parameters are: α1 = 0.7594, β^1=0.3616, α2 = 1.1359, β^2=1.6092. The estimated 95% confidence intervals for the common gamma mean by all the proposed methods are presented in Table 6. Given sample sizes 18 and 17 and parameter estimates, the confidence interval estimated by GVK is most recommenced in practice.

Table 5. Chloride concentration (in mg/litre) in water data. [30].

Granodiorite Quartz Monzonite
6.0, 0.5, 0.4, 0.7, 0.8, 6.0, 5.0, 0.6, 1.2 1.0, 0.2, 1.2, 1.0, 0.3, 0.1, 0.1, 0.4, 3.2
1.0, 0.2, 1.2, 1.0, 0.3, 0.1, 0.1, 0.4, 3.2 0.3, 0.4, 1.8, 0.9, 0.1, 0.2, 0.3, 0.5

Table 6. Estimated confidence intervals and lengths for the common mean for Chloride concentration (in mg/litre) in water.

method lower upper length
GV K 0.524 1.366 0.842
GV C 0.555 1.482 0.928
GV W 0.547 1.455 0.908
MOVER K 0.543 1.251 0.707
MOVER C 0.569 1.317 0.749
MOVER W 0.571 1.317 0.746
MOVER boot 0.567 1.310 0.743

Summary and discussion

Gamma distribution plays an important role in practice. When the result of testing equality of several gamma means is not significant, it is customary that we need to make inference about the common gamma mean. While the standard large sample methods exist, small sample inference for the common gamma mean has not been explored. In this article, we focus on accurate confidence interval estimation for the common gamma mean based on several independent gamma samples using the concepts of generalized pivots and the method of MOVER. Via a comprehensive simulation study, we discovered that the proposed methods based on generalized pivots can generally provide satisfactory confidence intervals with consistent performance despite parameter settings and sample sizes. The MOVER-type methods can be liberal for certain scenarios, especially when sample sizes are small.

The proposed methods are easy to implement. The R program is available at li.yan@roswellpark.org.

Due to the popularity of gamma distribution in applied fields, we expect the proposed methods have wide applicability in practice where right-skewed data are often observed.

Data Availability

All relevant data are within the paper.

Funding Statement

The author(s) received no specific funding for this work.

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Decision Letter 0

Miguel A Fernández

11 Jan 2022

PONE-D-21-27089Confidence interval estimation of the common mean of several gamma populationsPLOS ONE

Dear Dr. Yan,

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Reviewer #1: The author has addressed the problem of estimating the common mean of several gamma distributions. He has proposed several confidence intervals (CIs) based on the generalized variable approach, MOVER and likelihood approach. The proposed CIs are evaluated and compared with respect to coverage probabilities and expected widths. In general, the paper is easy to read and I have the following comments and suggestions.

Reviewer #2: The paper considers constructing confidence interval for the common mean of gamma distributed samples and the author proposes two category of methods which are validated by using simulations. Although the numerical results are very good, I have a concern of the theoretical foundation of the proposed method. Below are my major comments.

1. What is the rationale behind the constructed GPQs (11) and (12)? Are they valid GPQs? Are there any theoretical guarantees of using them in constructing the confidence intervals?

2. Line 113, Step 3. Is it Eq (8) or Eq (3)?

3. The common mean problem of the gamma distribution has been well identified in the literature, as the author claimed. There must be some existing methods in constructing the confidence interval. The author needs to compare the proposed methods with the existing ones using simulations.

4. For the examples, why is it important to assume a common mean for the two samples? It seems that confidence intervals can be well constructed for each individual sample.

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PLoS One. 2022 Jun 17;17(6):e0269971. doi: 10.1371/journal.pone.0269971.r002

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Decision Letter 1

Miguel A Fernández

10 Mar 2022

PONE-D-21-27089R1Confidence interval estimation of the common mean of several gamma populationsPLOS ONE

Dear Dr. Yan,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

The paper has certainly improved in the revision. Hoewever, given the reviewers' comments I think we need another round of revision. Please adress all concerns raised, especially those expressed by the second reviewer.

Please submit your revised manuscript by Apr 24 2022 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

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Academic Editor

PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: (No Response)

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Partly

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The tables need ti be reformatted. Columns of coverage probabilities and corresponding expected widths are not in alignment. Sample sizes are not reported for the case of four populations.

Reviewer #2: I appreciate the author's efforts in addressing my comments but I still have concerns regarding some responses.

Firstly, in my previous Comment#1, what I asked is whether the constructed GPQs are valid. There are two conditions for a valid GPQ and the author needs to check them. In addition, it is good to see the superb performance of the GPQ method, but is there any theoretical guarantee? If no, probably the good performance is just because of the simulation settings. The author needs to provide some insights in using GPQs.

Secondly, in the response to my Comment#3, the authors mentioned all other methods do not perform well at finite sample sizes. I do not see the rational between the two sentences ""In page 2, some large sample approach was presented" and "However, as expected, its confidence intervals can be severely liberal". The authors clearly do not conduct numerical simulations so what is the evidence of "expectation"? I would suggest adding simulation results from other methods to the paper to better highlight the contribution.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

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Reviewer #1: No

Reviewer #2: No

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

PLoS One. 2022 Jun 17;17(6):e0269971. doi: 10.1371/journal.pone.0269971.r004

Author response to Decision Letter 1


22 Apr 2022

The response to reviewers were uploaded in pdf files (Responses to reviewer 1_R2.pdf

and Responses to reviewer 2_R2.pdf) for proper format

Attachment

Submitted filename: Responses to reviewer 2_R2.pdf

Decision Letter 2

Miguel A Fernández

2 Jun 2022

Confidence interval estimation of the common mean of several gamma populations

PONE-D-21-27089R2

Dear Dr. Yan,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Miguel A. Fernández, Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: As noted in the paper, inferences for a single gamma

mean or for comparison of several gamma means have been well studied. However, research on the common mean of several gamma

populations are sparse. This paper addresses the problem of confidence interval

estimation of the common mean of several gamma populations using the fiducial inference. Simulation studies have been carried out to judge the accuracy of the proposed methods

I have no further comments. The manuscript maybe accepted as it is.

Reviewer #2: (No Response)

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Kalimuthu Krishnamoorthy

Reviewer #2: No

**********

Acceptance letter

Miguel A Fernández

10 Jun 2022

PONE-D-21-27089R2

Confidence Interval Estimation of the Common Mean of Several Gamma Populations

Dear Dr. Yan:

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department.

If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org.

If we can help with anything else, please email us at plosone@plos.org.

Thank you for submitting your work to PLOS ONE and supporting open access.

Kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr Miguel A. Fernández

Academic Editor

PLOS ONE

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    Attachment

    Submitted filename: Report.pdf

    Attachment

    Submitted filename: Responses_to_reviewer_2.pdf

    Attachment

    Submitted filename: Responses to reviewer 2_R2.pdf

    Data Availability Statement

    All relevant data are within the paper.


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