Table 1.
Summary of experiment 1 and 2 data. Arrows depict direction of change of significant main effects or interactions.
| Males | Females | |||
|---|---|---|---|---|
| Effect of Maternal Separation (MS360 relative to MS15) | Effect of oxytocin on maternal separation | Effect of Maternal Separation | Effect of oxytocin on maternal separation | |
| Anxiety | ||||
| Time in Closed Arm on EPM | ↑ | ↓ | ↑ | ↓ |
| Social Behaviour | ||||
| Social Interaction (General Investigation) | – | – | ↑ | – |
| Social Interaction (Anogenital Sniffing) | ↑ | – | ↑ | – |
| Social Interaction (Aggressive behaviour) | ↑ | – | ↑ | – |
| Methamphetamine addiction outcomes | ||||
| Methamphetamine self-administration (0.03 mg/kg) | ↑ | – | – | – |
| Methamphetamine self-administration (0.1 mg/kg) | ↑ | ↓ | – | – |
| Lifetime methamphetamine intake (mg/kg) | ↑ | ↓ | – | – |
| Days to extinction criterion | ↑ | ↓ | – | – |
| Cue-induced reinstatement | ↑ | – | – | – |
| Meth-primed reinstatement (0.3 mg/kg) | – | - | - | - |
| Meth-primed reinstatement (1 mg/kg) | ↑ | ↓ | ↑ | ↓ |
| Yohimbine-primed reinstatement (0.625 mg/kg) | – | – | ↑ | ↓ |
| Yohimbine-primed reinstatement (1.25 mg/kg) | ↑ | ↓ | ↑ | – |
| Brain and blood markers | ||||
| Hypothalamic oxytocin cell counts | ↓ | ↑ | ↓ | – |
| Hypothalamic CRF cell counts | ↑ | – | ↑ | – |
| Plasma oxytocin levels | ↑ | ↓ | – | – |
| Plasma corticosterone levels | ↑ | ↓ | ↑ | ↓ |